A global effort is currently undertaken to restrain the COVID-19 pandemic. Host immunity has come out as a determinant for COVID-19 clinical outcomes, and several studies investigated the immune profiling of SARS-CoV-2 infected people to properly direct the clinical management of the disease. Thus, lymphopenia, T-cell exhaustion, and the increased levels of inflammatory mediators have been described in COVID-19 patients, in particular in severe cases 1 . Age represents a key factor in COVID-19 morbidity and mortality 2 . Understanding age-associated immune signatures of patients are therefore important to identify preventive and therapeutic strategies. In this study, we investigated the immune profile of COVID-19 hospitalized patients identifying a distinctive age-dependent immune signature associated with disease severity. Indeed, defined circulating factors – CXCL8, IL-10, IL-15, IL-27, and TNF-α – positively correlate with older age, longer hospitalization, and a more severe form of the disease and may thus represent the leading signature in critical COVID-19 patients.
【저자키워드】 Translational research, Predictive markers, 【초록키워드】 COVID-19, SARS-CoV-2, Immunity, Hospitalization, COVID-19 pandemic, disease severity, Immune profile, clinical outcomes, lymphopenia, immune profiling, Patient, Older age, Therapeutic strategies, understanding, Clinical management, morbidity and mortality, IL-10, T-cell exhaustion, COVID-19 patients, TNF-α, CXCL8, IL-15, Factor, effort, Severe case, circulating, key factor, critical COVID-19 patients, IL-27, inflammatory mediator, immune signature, defined, described, identify, investigated, the disease, hospitalized patient, 【제목키워드】 cytokine, Patient, reveal,