The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious public health threat worldwide with millions of people at risk in a growing number of countries. Though there are no clinically approved antiviral drugs and vaccines for COVID-19, attempts are ongoing for clinical trials of several known antiviral drugs, their combination, as well as development of vaccines in patients with confirmed COVID-19. This review focuses on the latest approaches to diagnostics and therapy of COVID-19. We have summarized recent progress on the conventional therapeutics such as antiviral drugs, vaccines, anti-SARS-CoV-2 antibody treatments, and convalescent plasma therapy which are currently under extensive research and clinical trials for the treatment of COVID-19. The developments of nanoparticle-based therapeutic and diagnostic approaches have been also discussed for COVID-19. We have assessed recent literature data on this topic and made a summary of current development and future perspectives.
【저자키워드】 ARDS, Immunotherapy, antiviral drugs, Convalescent plasma therapy, anti-SARS-CoV-2 antibody, antiviral vaccines, nanotherapeutics, 【초록키워드】 COVID-19, Treatment, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, Vaccine, coronavirus, clinical trial, pandemic, therapy, Vaccines, antiviral drugs, diagnostic, clinical trials, risk, severe acute respiratory syndrome Coronavirus, diagnostics, antiviral drug, Convalescent plasma therapy, therapeutic, Research, Patient, nanoparticle, respiratory, Combination, acute respiratory syndrome, Topic, treatment of COVID-19, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, public health threat, caused, approach, clinically, approved, 【제목키워드】 COVID-19, development, recent,