Highlights • Antivirus activities, adverse reactions, advance on COVID-19 treatment, and general usage of potential chemical drugs against SARS-CoV-2 are summarized. • Various TCMs with practical effects, including Chinese herbal compound prescriptions, injection preparations, and active ingredients of TCMs, on the treatment of COVID-19 are reviewed. • Biological products, such as interferon-α, vaccines, stem cells, and convalescent plasma, are concluded to treat COVID-19. The fight against the novel coronavirus pneumonia (namely COVID-19) that seriously harms human health is a common task for all mankind. Currently, development of drugs against the novel coronavirus (namely SARS-CoV-2) is quite urgent. Chinese medical workers and scientific researchers have found some drugs to play potential therapeutic effects on COVID-19 at the cellular level or in preliminary clinical trials. However, more fundamental studies and large sample clinical trials need to be done to ensure the efficacy and safety of these drugs. The adoption of these drugs without further testing must be careful. The relevant articles, news, and government reports published on the official and Preprint websites, PubMed and China National Knowledge Infrastructure (CNKI) databases from December 2019 to April 2020 were searched and manually filtered. The general pharmacological characteristics, indications, adverse reactions, general usage, and especially current status of the treatment of COVID-19 of those potentially effective drugs, including chemical drugs, traditional Chinese medicines (TCMs), and biological products in China were summarized in this review to guide reasonable medication and the development of specific drugs for the treatment of COVID-19.
【저자키워드】 COVID-19, severe acute respiratory syndrome coronavirus 2, convalescent plasma, SARS-CoV-2, Coronavirus disease 2019, Randomized controlled trials, acute respiratory distress syndrome, COVID-19, Coronavirus disease 2019, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, HIV, Human immunodeficiency virus, C-reactive protein, Mesenchymal stem cells, severe acute respiratory syndrome Coronavirus, novel coronavirus pneumonia, Toujie Quwen granule, Lianhua Qingwen capsule, Qingfei Paidu decoction, glycyrrhizic acid, respiratory syncytial virus, Middle East respiratory syndrome Coronavirus, dengue virus, COPD, Chronic obstructive pulmonary disease, SARS-CoV, severe acute respiratory syndrome coronavirus, RSV, respiratory syncytial virus, MERS-CoV, Middle East respiratory syndrome coronavirus, Human immunodeficiency virus, ARDS, acute respiratory distress syndrome, chronic obstructive pulmonary disease, Interferon-α, traditional Chinese medicines, CRP, C-reactive protein, COVID-19coronavirus disease 2019, SARS-CoV-2severe acute respiratory syndrome coronavirus 2, ARDSacute respiratory distress syndrome, RCTs, randomized controlled trials, CNKI, China National Knowledge Infrastructure, NCP, novel coronavirus pneumonia, TCMs, traditional Chinese medicines, DENV, dengue virus, EC50, half effective concentration, RTP, ribofuranosyl-5′-triphosphate, MNV, murine norovirus, GA, glycyrrhizic acid, ACE2, angiotensin converting enzyme II, HXZQ, Huoxiang Zhengqi, JHQG, Jinhua Qinggan Granule, LHQW, Lianhua Qingwen Capsule, Shufeng SFJD, Jiedu Capsule, FFTS, Fangfeng Tongsheng Pill, QFPD, Qingfei Paidu Decoction, TJQW, Toujie Quwen Granule, HSBD, Huashi Baidu Prescription, XFBD, Xuanfei Baidu Decoction, CP, convalescent plasma, IFN-α, interferon-α, NK, natural killer, MSCs, mesenchymal stem cells, Chemical drugs, Biological products, RCTsrandomized controlled trials, CNKIChina National Knowledge Infrastructure, China National Knowledge Infrastructure, NCPnovel coronavirus pneumonia, TCMstraditional Chinese medicines, SARS-CoVsevere acute respiratory syndrome coronavirus, MERS-CoVmiddle east respiratory syndrome coronavirus, HIVhuman immunodeficiency virus, RSVrespiratory syncytial virus, DENVdengue virus, EC50half effective concentration, half effective concentration, RTPribofuranosyl-5′-triphosphate, ribofuranosyl-5′-triphosphate, MNVmurine norovirus, murine norovirus, GAglycyrrhizic acid, ACE2angiotensin converting enzyme II, angiotensin converting enzyme II, HXZQHuoxiang Zhengqi, Huoxiang Zhengqi, JHQGJinhua Qinggan Granule, Jinhua Qinggan Granule, CRPC-reactive protein, LHQWLianhua Qingwen Capsule, Shufeng SFJDJiedu Capsule, Jiedu Capsule, FFTSFangfeng Tongsheng Pill, Fangfeng Tongsheng Pill, QFPDQingfei Paidu Decoction, TJQWToujie Quwen Granule, HSBDHuashi Baidu Prescription, Huashi Baidu Prescription, XFBDXuanfei Baidu Decoction, Xuanfei Baidu Decoction, COPDchronic obstructive pulmonary disease, CPconvalescent plasma, IFN-αinterferon-α, NKnatural killer, natural killer, MSCsmesenchymal stem cells, 【초록키워드】 Treatment, stem cells, clinical trial, Vaccines, Pneumonia, drugs, clinical trials, Traditional Chinese medicine, drug, database, Novel coronavirus, effective drugs, Adverse reactions, China, Health, Characteristics, Efficacy and safety, ingredient, medication, cellular, TCM, Biological, Government, Infrastructure, indications, Chinese, activities, injection, therapeutic effect, treat, CNKI, large sample, researcher, pharmacological, Effects, articles, searched, filtered, 【제목키워드】 Treatment, Pneumonia, drug, Novel coronavirus, China, Potential,