[저자] Adriana Tomic, Donal T. Skelly, Ane Ogbe, Daniel O’Connor, Matthew Pace, Emily Adland, Frances Alexander, Mohammad Ali, Kirk Allott, M. Azim Ansari, Sandra Belij-Rammerstorfer, Sagida Bibi, Luke Blackwell, Anthony Brown, Helen Brown, Breeze Cavell, Elizabeth A. Clutterbuck, Thushan de Silva, David Eyre, Sheila Lumley, Amy Flaxman, James Grist, Carl-Philipp Hackstein, Rachel Halkerston, Adam C. Harding, Jennifer Hill, Tim James, Cecilia Jay, Síle A. Johnson, Barbara Kronsteiner, Yolanda Lie, Aline Linder, Stephanie Longet, Spyridoula Marinou, Philippa C. Matthews, Jack Mellors, Christos Petropoulos, Patpong Rongkard, Cynthia Sedik, Laura Silva-Reyes, Holly Smith, Lisa Stockdale, Stephen Taylor, Stephen Thomas, Timothy Tipoe, Lance Turtle, Vinicius Adriano Vieira, Terri Wrin,
OPTIC Clinical GroupStaffordLizzie3AbuelgasimHibatullah24AlhussniAhmed24Arancibia-CárcamoCarolina V.23BorakMartyna23CutteridgeJoseph24DeeksAlexandra23DenlyLucy24DimitriadisStavros21FassihShayan13FoordThomas24FordwohThomas24HolmesJennifer24HorsingtonBryn1KerneisSven3KimDavid24LillieKaty24MorrowJordan3O’DonnellDenise21RitterThomas G.24SimmonsBeatrice3TaylorAdan24ThomasSarah R.13WarrenYolanda21WatsonAdam J. R.24WeeksEsme24WilsonRobert24YoungRebecca24
, Lizzie Stafford, Hibatullah Abuelgasim, Ahmed Alhussni, Carolina V. Arancibia-Cárcamo, Martyna Borak, Joseph Cutteridge, Alexandra Deeks, Lucy Denly, Stavros Dimitriadis, Shayan Fassih, Thomas Foord, Thomas Fordwoh, Jennifer Holmes, Bryn Horsington, Sven Kerneis, David Kim, Katy Lillie, Jordan Morrow, Denise O’Donnell, Thomas G. Ritter, Beatrice Simmons, Adan Taylor, Sarah R. Thomas, Yolanda Warren, Adam J. R. Watson, Esme Weeks, Robert Wilson, Rebecca Young,
PITCH Study GroupDuncanChristopher J. A.2526MooreShona C.27PayneRebecca28RichterAlex2930Rowland-JonesSarah3132
, Christopher J. A. Duncan, Shona C. Moore, Rebecca Payne, Alex Richter, Sarah Rowland-Jones,
C-MORE GroupMentzerAlexander J.316CassarMark Philip35DongTao223334FriesAnastasia35Gilbert-JaramilloJavier35HoLing-Pei2233KnightJulian C.316NeubauerStefan322PengYanchun223334PetousiNayia321RamanBetty322TalbotNick P.335
, Alexander J. Mentzer, Mark Philip Cassar, Tao Dong, Anastasia Fries, Javier Gilbert-Jaramillo, Ling-Pei Ho, Julian C. Knight, Stefan Neubauer, Yanchun Peng, Nayia Petousi, Betty Raman, Nick P. Talbot, Andrew J. Pollard, Teresa Lambe, Chris P. Conlon, Katie Jeffery, Simon Travis, Philip Goulder, John Frater, Alex J. Mentzer, Lizzie Stafford, Miles W. Carroll, William S. James, Paul Klenerman, Eleanor Barnes, Christina Dold, Susanna J. Dunachie
[Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 진단, 치료제,
[Article Type] Article
[Source] PMC
The trajectories of acquired immunity to severe acute respiratory syndrome coronavirus 2 infection are not fully understood. We present a detailed longitudinal cohort study of UK healthcare workers prior to vaccination, presenting April-June 2020 with asymptomatic or symptomatic infection. Here we show a highly variable range of responses, some of which (T cell interferon-gamma ELISpot, N-specific antibody) wane over time, while others (spike-specific antibody, B cell memory ELISpot) are stable. We use integrative analysis and a machine-learning approach (SIMON – Sequential Iterative Modeling OverNight) to explore this heterogeneity. We identify a subgroup of participants with higher antibody responses and interferon-gamma ELISpot T cell responses, and a robust trajectory for longer term immunity associates with higher levels of neutralising antibodies against the infecting (Victoria) strain and also against variants B.1.1.7 (alpha) and B.1.351 (beta). These variable trajectories following early priming may define subsequent protection from severe disease from novel variants. The engagement of immunological memory is a key component to the protective anti-SARS-CoV-2 B and T cell responses. Here the authors assess the B and T cells of a cohort of UK healthcare workers in response to infection and longitudinally track the compartment showing distinct trajectories following early priming.
All Keywords
【저자키워드】 SARS-CoV-2, viral infection, Infection, Immunological memory, 【초록키워드】 coronavirus, vaccination, Immunity, antibody, B.1.351, Antibody Response, variant, anti-SARS-CoV-2, variants, heterogeneity, healthcare worker, Cohort, T cell, Asymptomatic, B.1.1.7, B cell memory, neutralising antibody, T cell responses, modeling, Alpha, trajectory, ELISPOT, Integrative analysis, machine-learning, Protective, symptomatic infection, severe disease, acute respiratory syndrome, Victoria, longitudinal cohort study, participant, priming, infecting, Spike-specific antibody, responses, approach, robust, identify, subsequent, presenting, 【제목키워드】 Antiviral, SARS-COV-2 infection, memory, trajectory,