Graphical abstract Highlights • Therapeutic drugs with plausible efficacy against COVID-19 have been reviewed. • Notable drugs, antiviral compounds and natural products against COVID-19 were discussed. • Different drugs were appraised to ascertain the current state of COVID-19 management. The disease caused by viral pneumonia called severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2) declared by the World Health Organization is a global pandemic that the world has witnessed since the last Ebola epidemic, SARS and MERS viruses. Many chemical compounds with antiviral activity are currently undergoing clinical investigation in order to find treatments for SARS-CoV-2 infected patients. On-going drug-drug interaction examinations on new, existing, and repurposed antiviral drugs are yet to provide adequate safety, toxicological, and effective monitoring protocols. This review presents an overview of direct and indirect antiviral drugs, antibiotics, and immune-stimulants used in the management of SARS-CoV-2. It also seeks to outline the recent development of drugs with anti-coronavirus effects; their mono and combination therapy in managing the disease vis-à-vis their biological sources and chemistry. Co-administration of these drugs and their interactions were discussed to provide significant insight into how adequate monitoring of patients towards effective health management could be achieved.
【저자키워드】 COVID-19, Therapeutics, antiviral drugs, ACE2, angiotensin-converting enzyme 2, HA, hemagglutinin, drug interaction, WHO, World Health Organization, 3CLpro, 3-chymotrypsin-like protease, Health and safety, NLRP3, (Nucleotide Oligomerization Domain)-like receptor protein 3 (NLRP3) Inflammasome activation, MERS-CoV, Middle East Respiratory Syndrome Corona Virus, SARS-CoV, Severe Acute Respiratory Syndrome Corona Virus, RpRd, RNA-dependent RNA polymerase, CQ, Chloroquine, HCQ, hydroxychloroquine, US-FDA, Food and Drug Administration, EC50, Half maximal Effective concentration, Mpro, Main Protease Enzymes, Hb, Haemoglobin, CC50, Half-maximal Cytotoxic Concentration, EC50, Half-maximal Effective Concentration, RpRd, RNA-dependent RNA polymerase, QTc, the Corrected interval between the wave of Q and T, 【초록키워드】 Treatment, viruses, SARS-CoV-2, Efficacy, coronavirus, drugs, Antibiotics, combination therapy, drug, antiviral activity, MERS, antiviral drug, global pandemic, Viral pneumonia, Epidemic, Health, management, Patient, Ebola, disease, drug-drug interaction, Interaction, protocols, World Health Organization, acute respiratory syndrome, Abstract, SARS-CoV-2 infected patients, Compound, clinical investigation, Antiviral compound, effective, caused, the disease, 【제목키워드】 SARS-CoV-2, drug, Perspective, current,