Abstract Numerous viral pneumonia cases have been reported in Wuhan, Hubei in December 2019. The pathogen has been identified as a novel coronavirus, which was named severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). The biological characteristics and pathogenesis mechanism of SARS‐CoV‐2 are unclear and under progress. At present, no specific preventive and therapeutic drugs are available. Animal models can reproduce the viral replication cycle and the significant functions of respiratory coronavirus infection and are urgently needed to evaluate the efficacy of drugs and vaccines, the transmission route of respiratory coronavirus, clinical features, and so on. We reviewed the current animal models of respiratory coronavirus (SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2) infection and made a comparative analysis of the route of inoculation, virus replication, clinical signs, histopathology, application, advantages, and disadvantages. Animal models of respiratory coronavirus include susceptible animal models, genetically modified models, and various animal models of infected virus adaptation strains, such as nonhuman primates, mice, hamsters, ferrets, New Zealand rabbits, cats, and other animal models, all of which have distinct advantages and limitations. This review will provide relevant information and important insights for disease management and control. Highlight Animal models for coronavirus infection.
【저자키워드】 Coronavirus infection, SARS‐CoV‐2, animal model, mechanism, 【초록키워드】 Efficacy, coronavirus, Pathogenesis, Vaccines, hamsters, Infection, Transmission, drug, animal models, virus, Clinical features, Histopathology, Novel coronavirus, SARS‐CoV‐2, Viral pneumonia, Characteristics, pathogen, mice, viral replication, animal, management, Wuhan, virus replication, Clinical signs, information, disease, Strains, function, Disadvantages, Analysis, acute respiratory syndrome, ferrets, limitations, susceptible, Respiratory Coronavirus, evaluate, include, reported, New, Numerous, therapeutic drug, 【제목키워드】 review, Infection, Research, Respiratory Coronavirus, selected,