Abstract Coronavirus disease 2019 (COVID‐19) has caused a global pandemic that continues to cause numerous deaths to date. Four vaccines have been approved by the Food and Drug Administration as of July 2021 to prevent the transmission of COVID‐19: Pfizer, Moderna, AstraZeneca, and Janssen. These vaccines have shown great efficacy and safety profile. One side effect that has been widely reported is post‐COVID‐19 vaccination lymphadenopathy. Due to the mimicry of the lymphadenopathy for metastases in some oncologic patients, there have been reports of patients who underwent biopsies that showed pathologic confirmation of benign reactive lymphadenopathy secondary to the COVID‐19 vaccine. Therefore, understanding the incidence of lymphadenopathy post‐COVID‐19 vaccinations will help guide radiologists and oncologists in their management of patients, both present oncologic patients, and patients with concerns over their newly presenting lymphadenopathy. A systematic literature search was performed using several databases to identify relevant studies that reported lymphadenopathy post‐COVID‐19 vaccination. Our results revealed that several cases have been detected in patients undergoing follow‐up fluorodeoxyglucose (FDG)‐positron emission tomography‐computerized tomography scans where lymph nodes ipsilateral to the vaccine injection site show increased uptake of FDG. Thus, knowledge of the incidence of lymphadenopathy may help avoid unnecessary biopsies, interventions, and changes in management for patients, especially oncologic patients who are at risk for malignancies. Highlights Lymphadenopathy has been widely reported post‐COVID‐19 vaccination including patients undergoing follow‐up FDG‐PET‐CT scans which showed increased FDG uptake Care must be taken before suspecting lymph node metastasis or deciding for lymphadenectomy following COVID‐19 vaccination
【저자키워드】 COVID‐19, coronavirus, Pfizer, Moderna, janssen, Lymphadenopathy, AztraZeneca, COVID‐19 vacccine, fluorodeoxyglucose (FDG) PET‐CT scan, 【초록키워드】 Coronavirus disease 2019, Vaccine, vaccination, knowledge, risk, tomography, Transmission, drug, database, COVID‐19, global pandemic, biopsies, management, Patient, death, Efficacy and safety, incidence, patients, FDG, AstraZeneca, food, Metastasis, biopsy, Lymph node, Side effect, help, injection, malignancies, systematic literature search, radiologist, Prevent, oncologist, reactive, shown, identify, caused, reported, pathologic, approved, was performed, changes in, the vaccine, presenting, ipsilateral, 【제목키워드】 vaccination, systematic review, FDG,