Abstract A severe pandemic of Coronavirus Disease (COVID‐19) has been sweeping the globe since 2019, and this time, it did not stop, with frequent mutations transforming into virulent strains, for instance, B.1.1.7, B.1.351, and B.1.427. In recent months, a fungal infection, mucormycosis has emerged with more fatal responses and significantly increased mortality rate. To measure the severity and potential alternative approaches against black fungus coinfection in COVID‐19 patients, PubMed, Google Scholar, World Health Organization (WHO) newsletters, and other online resources, based on the cases reported and retrospective observational analysis were searched from the years 2015–2021. The studies reporting mucormycosis with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) coinfection and/or demonstrating potential risk factors, such as a history of diabetes mellitus or suppressed immune system were included, and reports published in non‐English language were excluded. More than 20 case reports and observational studies on black fungus coinfection in COVID‐19 patients were eligible for inclusion. The results indicated that diabetes mellitus, hyperglycemic, and immunocompromised COVID‐19 patients with mucormycosis were at a higher risk. We found that it was prudent to assess the potential risk factors and severity of invasive mycosis via standardized diagnostic and clinical settings. Large‐scale studies need to be conducted to identify early biomarkers and optimization of diagnostic methods has to be established per population and geographical variation. This will not only help clinicians around the world to detect the coinfection in time but also will prepare them for future outbreaks of other potential pandemics. Highlights Observational studies and case reports of Post‐COVID black fungus co‐infection highlighted in review. Along with risk factors, radiological interventions of black fungus co‐infection in COVID‐19 patients and challenges for accurate diagnosis were elaborated. The review discusses interconnection between fungus and SARS‐CoV‐2 co‐infection of mechanism to identify potential biomarkers. Our conclusion will contribute to motivate researchers to design follow‐up plans for black fungus infection in COVID‐19.
【저자키워드】 COVID‐19, Diagnosis, Mucormycosis, Black fungus, Fungal infection, 【초록키워드】 pandemic, Biomarker, Mutation, Risk factors, B.1.351, severity, Variation, Infection, Diabetes Mellitus, diagnostic, Intervention, immune system, coronavirus 2, observational study, Case report, COVID‐19, SARS‐CoV‐2, B.1.427, B.1.1.7, response, Factors, Immunocompromised, Pandemics, WHO, mortality rate, respiratory, Strains, mechanism, Diagnostic method, retrospective, Analysis, Google Scholar, World Health Organization, Mycosis, Factor, higher risk, clinician, potential risk, help, clinical settings, potential biomarkers, virulent, researcher, resources, approach, invasive, radiological, significantly increased, identify, detect, globe, reported, indicated, conducted, searched, contribute, suppressed, COVID‐19 patient, eligible, for inclusion, were excluded, 【제목키워드】 systematic review,