In this commentary, we shed light on the role of the mammalian target of rapamycin (mTOR) pathway in viral infections. The mTOR pathway has been demonstrated to be modulated in numerous RNA viruses. Frequently, inhibiting mTOR results in suppression of virus growth and replication. Recent evidence points towards modulation of mTOR in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We discuss the current literature on mTOR in SARS-CoV-2 and highlight evidence in support of a role for mTOR inhibitors in the treatment of coronavirus disease 2019.
All Keywords
【저자키워드】 COVID-19, mTOR, mTORi, 【초록키워드】 Treatment, coronavirus disease, SARS-CoV-2, coronavirus, Infection, Replication, Rapamycin, infections, RNA viruses, pathway, Evidence, Support, acute respiratory syndrome, modulation, mammalian, virus growth, mTOR inhibitor, recent, highlight, in viral, demonstrated, inhibiting, modulated, Frequently, 【제목키워드】 Efficacy, RNA virus,
【저자키워드】 COVID-19, mTOR, mTORi, 【초록키워드】 Treatment, coronavirus disease, SARS-CoV-2, coronavirus, Infection, Replication, Rapamycin, infections, RNA viruses, pathway, Evidence, Support, acute respiratory syndrome, modulation, mammalian, virus growth, mTOR inhibitor, recent, highlight, in viral, demonstrated, inhibiting, modulated, Frequently, 【제목키워드】 Efficacy, RNA virus,