The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases. The risk of life-threatening COVID-19 pneumonia increases sharply after 65 years of age, but other epidemiological risk factors, genetic or otherwise, are modest. Various rare monogenic inborn errors of type I interferons (IFNs) underlie critical disease, and neutralizing autoantibodies against type I IFNs account for at least 10% of critical cases.
All Keywords
【초록키워드】 COVID-19, Risk factors, Pneumonia, Genetic, risk, type I interferon, age, epidemiological, Neutralizing, IFNs, Critical disease, critical cases, Type I IFN, autoantibody, life-threatening, increase, underlie, monogenic inborn error,
【초록키워드】 COVID-19, Risk factors, Pneumonia, Genetic, risk, type I interferon, age, epidemiological, Neutralizing, IFNs, Critical disease, critical cases, Type I IFN, autoantibody, life-threatening, increase, underlie, monogenic inborn error,