In this Letter to the Editor we report the case of two siblings with fatal pneumococcal meningitis as the initial manifestation of IRAK-4 deficiency caused by previously undescribed mutations in IRAK4. The letter also highlights the importance of invasive pneumococcal infection as a critical ‘red flag’ warning of the potential for an underlying primary immunodeficiency and identifies some of the challenges in making the clinical diagnosis of IRAK-4 deficiency.
All Keywords
【저자키워드】 Primary Immunodeficiency, Meningitis, Streptococcus pneumoniae, invasive pneumococcal disease, IRAK-4 deficiency, Toll-like receptor signaling.,
【저자키워드】 Primary Immunodeficiency, Meningitis, Streptococcus pneumoniae, invasive pneumococcal disease, IRAK-4 deficiency, Toll-like receptor signaling.,