COVID-19 is still a deadly disease that remains yet a major challenge for humans. In recent times, many large pharmaceutical and non-pharmaceutical companies have invested a lot of time and cost in fighting this disease. In this regard, today’s scientific knowledge shows that designing and producing an effective vaccine is the best possible way to diminish the disease burden and dissemination or even eradicate the disease. Due to the urgent need, many vaccines are now available earlier than scheduled. New technologies have also helped to produce much more effective vaccines, although the potential side effects must be taken into account. Thus, in this review, the types of vaccines and vaccine designs made against COVID-19, the vaccination programs, as well as the delivery methods and molecules that have been used to deliver some vaccines that need a carrier will be described.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, Vaccine design, vaccine delivery, RSV, respiratory syncytial virus, RBD, receptor binding domain, VLP, virus-like particle, MERS, Middle East respiratory syndrome, CDC, Centers for Disease Control and Prevention, TLR, Toll-like receptor, SARS-COV-2, severe acute respiratory syndrome coronavirus-2, COVID-19, Coronavirus Disease-19, ACE2, Angiotensin Converting Enzyme 2, Coalition for Epidemic Preparedness Innovations, EUA, Emergency Use Authorization, SAGE, Strategic Advisory Group of Experts on Immunization, ASHP, American Society of Health-System Pharmacists, PRR, Pattern Recognition Receptors, PAMP, Pathogen-Associated Molecular Pattern, I.M., Intramuscular, S.C., Subcutaneous, APC, Antigen-Presenting Cell, WCA, Whole-Cell Antigen, LAV, Live-Attenuated Virus, Ad, Adenovirus, GMV, Genetically Modified Viruses, MVA, Modified Vaccinia Ankara, LMH, Live Modified Horsepox, VEE, Venezuelan Equine Encephalitis, Chimpanzee Adenoviral Vector 1, ChAdOx1, VRP, Virion Replicon Particle, LNP, Lipid Nanoparticles, 【초록키워드】 vaccination, knowledge, humans, dissemination, disease, Side effect, Effective vaccines, effective, described, the disease, producing, New, 【제목키워드】 approach,