Highlights • IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. • The use of corticosteroids might accelerate recovery from COVID-19. • No controlled clinical trials exist on the use of corticosteroids for COVID-19. • IL6 correlates with severity, criticality, viral load, and prognosis of COVID-19. • Tocilizumab, an anti-IL6, can confer benefit in patients with COVID-19 and high IL6. The novel coronavirus, SARS-CoV2, can cause a potentially fatal disease, COVID-19, in humans. Here, we will provide an overview of therapeutic options for COVID-19. Plasma from patients recovered from COVID-19 that contains antibodies against SARS-CoV2 has shown promising results in patients with severe COVID-19. Also, IVIG, combined with moderate-dose of corticosteroids, might improve patient outcomes. Evidence links COVID-19 to variable degrees of inflammation. Studies show that the use of corticosteroids might accelerate recovery from COVID-19. There are, however, no controlled clinical trials that show whether the use of corticosteroids can reduce COVID-19-related death. Also, the pro-inflammatory cytokine IL6 is the best-documented cytokine in COVID-19 correlated with severity, criticality, viral load, and prognosis of patients with COVID-19. Tocilizumab, a monoclonal antibody against IL6, could confer clinical benefit in patients with high IL6 levels. Essential elements that process SARS-CoV2 cell entry and specific characteristics that allow SARS-CoV2 to escape the immune system have the potential as targets for COVID-19 therapy.
【저자키워드】 COVID-19, Treatment, Corticosteroids, interleukin 6, Immunoglobulin, targeted therapy, 【초록키워드】 Inflammation, SARS-CoV2, therapy, severe COVID-19, Prognosis, antibody, severity, monoclonal antibody, IL6, cytokine, immune system, Novel coronavirus, outcomes, Characteristics, Viral load, humans, Patient, target, therapeutic option, essential element, anti-IL6, Controlled clinical trial, cell entry, clinical benefit, COVID-19-related death, pro-inflammatory cytokine, fatal disease, benefit, IMPROVE, shown, correlated, reduce, prognosis of patient, accelerate, patients with COVID-19, use of corticosteroid, with COVID-19, 【제목키워드】 Corticosteroid, immunoglobulins, Hypothesis, immunosuppressive, rationale,