A growing body of evidence indicates that obesity is strongly and independently associated with adverse outcomes of COVID-19, including death. By combining emerging knowledge of the pathological processes involved in COVID-19 with insights into the mechanisms underlying the adverse health consequences of obesity, we present some hypotheses regarding the deleterious impact of obesity on the course of COVID-19. These hypotheses are testable and could guide therapeutic and preventive interventions. As obesity is now almost ubiquitous and no vaccine for COVID-19 is currently available, even a modest reduction in the impact of obesity on mortality and morbidity from this viral infection could have profound consequences for public health. Obesity is associated with increased COVID-19-related mortality. Lockhart and O’Rahilly review the pathophysiological mechanisms that may underlie this link and converge on a set of testable hypotheses to guide investigation of the effects of obesity on COVID-19.
【초록키워드】 COVID-19, public health, viral infection, Mortality, knowledge, obesity, adverse outcome, Health, morbidity, therapeutic, death, mechanism, Evidence, Deleterious, pathophysiological mechanism, preventive interventions, Effect, consequence, Course, involved, indicate, reduction in, hypothese, underlie, vaccine for COVID-19, 【제목키워드】 COVID-19, Increased,