The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic taking the lives of millions. The virus itself not only invades and destroys the angiotensin-converting enzyme 2 (ACE2)-expressing cells of the lungs, kidneys, liver, etc . but also elicits a hyperinflammatory immune response, further damaging the tissue leading to acute respiratory distress syndrome (ARDS) and death. Although vaccines, as a prime example of active immunotherapy, have clearly disrupted the transmission of virus and reduced mortality, hospitalization, and burden of disease, other avenues of immunotherapy are also being explored. One such approach would be to adoptively transfer modified/unmodified immune cells to the critically ill. Here, we compiled and summarized the immunopathogenesis of SARS-CoV-2 and the recent preclinical and clinical data on the potential of cell-based therapies in the fight against COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, COVID-19, Coronavirus disease 2019, ACE2, angiotensin-converting enzyme 2, T cell, adoptive immunotherapy, CAR, Chimeric antigen receptor, MSC, mesenchymal stromal cell, NK cell, natural killer cell, iPSC, inuced pluripotent stem cell, DC, dendritic cell, CTL, cytotoxic T cell, GM-CSF, granulocyte monocyte colony-stimulating factor, VST, virus-specific T cell, ARDS, acute respiratory T cells, HLA, human leukocyte antigen, SARS, sever acute respiratory syndrome, 【초록키워드】 coronavirus disease, ARDS, coronavirus, immune response, Mortality, Hospitalization, Vaccines, Immunotherapy, Transmission, virus, angiotensin-converting enzyme 2, global pandemic, Critically ill, Lungs, Immunopathogenesis, death, disease, liver, acute respiratory distress, Cell-based therapy, Immune cell, acute respiratory syndrome, tissue, Clinical data, syndrome, kidneys, transfer, Hyperinflammatory, approach, Cell, caused, example, reduced, elicit, 【제목키워드】 Treatment, management, Cell-based therapy, recent finding,