The SARS-CoV-2 virus is still spreading worldwide, and there is an urgent need to effectively prevent and control this pandemic. This study evaluated the potential efficacy of Egg Yolk Antibodies (IgY) as a neutralizing agent against the SARS-CoV-2. We investigated the neutralizing effect of anti-spike-S1 IgYs on the SARS-CoV-2 pseudovirus, as well as its inhibitory effect on the binding of the coronavirus spike protein mutants to human ACE2. Our results show that the anti-Spike-S1 IgYs showed significant neutralizing potency against SARS-CoV-2 pseudovirus, various spike protein mutants, and even SARS-CoV in vitro . It might be a feasible tool for the prevention and control of ongoing COVID-19.
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【저자키워드】 SARS-CoV-2, IgY, Chicken Egg Yolk Antibodies, Spike protein variants, Neutralizing agent, 【초록키워드】 COVID-19, Efficacy, pandemic, SARS-CoV, SARS-CoV-2 virus, in vitro, Spike protein, human ACE2, pseudovirus, mutants, Neutralizing, coronavirus spike protein, SARS-CoV-2 pseudovirus, mutant, binding, inhibitory effect, yolk, neutralizing effect, Prevent, investigated, evaluated, feasible, Egg, the SARS-CoV-2, 【제목키워드】 variant, human ACE2, SARS-CoV-2 spike protein, binding, chicken, yolk, Egg,
【저자키워드】 SARS-CoV-2, IgY, Chicken Egg Yolk Antibodies, Spike protein variants, Neutralizing agent, 【초록키워드】 COVID-19, Efficacy, pandemic, SARS-CoV, SARS-CoV-2 virus, in vitro, Spike protein, human ACE2, pseudovirus, mutants, Neutralizing, coronavirus spike protein, SARS-CoV-2 pseudovirus, mutant, binding, inhibitory effect, yolk, neutralizing effect, Prevent, investigated, evaluated, feasible, Egg, the SARS-CoV-2, 【제목키워드】 variant, human ACE2, SARS-CoV-2 spike protein, binding, chicken, yolk, Egg,