[저자] Pere Millat-Martinez, Arvind Gharbharan, Andrea Alemany, Casper Rokx, Corine Geurtsvankessel, Grigorios Papageourgiou, Nan van Geloven, Carlijn Jordans, Geert Groeneveld, Francis Swaneveld, Ellen van der Schoot, Marc Corbacho-Monné, Dan Ouchi, Francini Piccolo Ferreira, Pierre Malchair, Sebastian Videla, Vanesa García García, Anna Ruiz-Comellas, Anna Ramírez-Morros, Joana Rodriguez Codina, Rosa Amado Simon, Joan-Ramon Grifols, Julian Blanco, Ignacio Blanco, Jordi Ara, Quique Bassat, Bonaventura Clotet, Bàrbara Baro, Andrea Troxel, Jaap Jan Zwaginga, Oriol Mitjà, Bart J. A. Rijnders,
CoV-Early study groupGharbharanArvind34RokxCasper34JordansCarlijn34GeurtsvankesselCorine34PapageourgiouGrigorios34RijndersBart34KatsikisPeter34MüllerYvonne34KoopmansMarion34BogersSusanne34MiedemaJelle34RusscherHenk34ScherpenisseCees34van EngenRene34KarisliAyten34GötzHannelore35StruikJelle36Rokx-NiemantsverdrietLotte36van GelovenNan37GroeneveldGeert37Jan ZwagingaJaap37ZwagingaLisa37OudJosine37MeierRomy37van ZwetErik37MooijaartSimon37AlbersenArjan37SwaneveldFrancis38van der SchootEllen38VrielinkHans38van de WateringLeo38HogemaBoris38van WijngaardenPeter39van EttenRonald39van GammerenAdriaan39MaasNanda39van GinnekenBetty39den HollanderJan40VerstijnenJose40van den Berg – RahmanJuliette40KarimFaiz41HiddemaSiepke41van ElstKim41van Leeuwen-SegarceanuElena42ReitsmaAnnette42MolenkampKarin42SoetekouwRobert43BandCaterina43de DroogJosé43LammersJolanda44BuitenhuisLonneke44PostmaDouwe45KosterDavid45LukensMichaèl45ScholtensThea45van den BoomgaardMaartje45VonkMachiel45KampschreurLinda46van VonderenMarit46VrolijkLoes46ReuskenChantal47ReimerinkJohan47HarvalaHeli48
, Arvind Gharbharan, Casper Rokx, Carlijn Jordans, Corine Geurtsvankessel, Grigorios Papageourgiou, Bart Rijnders, Peter Katsikis, Yvonne Müller, Marion Koopmans, Susanne Bogers, Jelle Miedema, Henk Russcher, Cees Scherpenisse, Rene van Engen, Ayten Karisli, Hannelore Götz, Jelle Struik, Lotte Rokx-Niemantsverdriet, Nan van Geloven, Geert Groeneveld, Jaap Jan Zwaginga, Lisa Zwaginga, Josine Oud, Romy Meier, Erik van Zwet, Simon Mooijaart, Arjan Albersen, Francis Swaneveld, Ellen van der Schoot, Hans Vrielink, Leo van de Watering, Boris Hogema, Peter van Wijngaarden, Ronald van Etten, Adriaan van Gammeren, Nanda Maas, Betty van Ginneken, Jan den Hollander, Jose Verstijnen, Juliette van den Berg – Rahman, Faiz Karim, Siepke Hiddema, Kim van Elst, Elena van Leeuwen-Segarceanu, Annette Reitsma, Karin Molenkamp, Robert Soetekouw, Caterina Band, José de Droog, Jolanda Lammers, Lonneke Buitenhuis, Douwe Postma, David Koster, Michaèl Lukens, Thea Scholtens, Maartje van den Boomgaard, Machiel Vonk, Linda Kampschreur, Marit van Vonderen, Loes Vrolijk, Chantal Reusken, Johan Reimerink, Heli Harvala,
COnV-ert study groupAlemanyAndrea49Corbacho-MonnéMarc49OuchiDan49ClotetBonaventura49MitjàOriol49CostesGèlia49Capdevila-JáureguiMar49Torrano-SolerPamela49San JoséAlba49JiménezZahida49Ramírez-ViaplanaFerran49FerrerSusana49GallardoMireia49UbalsMaria49González-BeirasCamila49Vall-MayansMartí49Rodriguez-AriasMiquel Angel49SuñerClara49PuigJordi49NietoAroa49Galvan-FemeniaIvan49Comas-LeonXavier49Millat-MartínezPere50BassatQuique50BaroBàrbara50BlancoIgnacio51AraJordi51Bonet PapellGlòria51Delgado CapelMaria51Díez SánchezBeatriz51Pons BarberMaria51Gonzalez RuizCristian51Navarrete GonzalezLaura51González GarcíaDavid51Vivero LarrazaAinhoa51Carceles PeiróVictor51Roquer LópezClàudia51FerrerMagí51MalchairPierre52VidelaSebastian52García GarcíaVanesa52GudiolCarlota52OteroAurema52Ruibal SuarezJose Carlos52PellejeroAlvaro Zarauza52Llopis RocaFerran52Rodriguez CortezOrlando52Casares GonzalezPablo52Arcos VilaGemma52Flores AguileraBegoña52Rodríguez-SevillaGraciela52Dastis AriasMacarena52Ruiz-ComellasAnna53Ramírez-MorrosAnna53Roca FontJudit53Carrasco MatosKatherine M.53Saüch ValmañaGlòria53Vidal ObradorsCarla53Rodríguez CodinaJoana54Amado SimonRosa54Tarres GarcíaSilvia54Curriu SabatèsMargarida54Nieto RodríguezRaquel54GrífolsJoan-Ramon55MillanAnna55ContrerasEnric55AncocheaÀgueda55LínioRosa55FornosMiriam55CasamitjanaNatàlia55AlonsoEva55MartinezNúria55MaglioLaura Analía55Comellas FernandezLaura55GarciaNadia55HernándezLuis55GonzálezMaría Isabel55BravoAnna55GarcíaYolanda55PratNúria56VerdaguerJoaquim56Vértiz GuidottiThatiana56BenaventSergio56BiancoAndrea Sofia56Briones ZambranoNey Nicanor56Viozquez MeyaMaria56ForcadaAnna57Vidal-AlaballJosep57GiménezMontserrat58ParísAlexa58Fernández RivasGema58Casañ LopezCristina58HernándezÁgueda58BordoyAntoni E.58González SolerVictoria58BlancoJulian59PradenasEdwars59MarfilSilvia59TrinitéBenjamin59Piccolo FerreiraFrancini60BonetMireia60CantoniJordi60MarksMichael61
, Andrea Alemany, Marc Corbacho-Monné, Dan Ouchi, Bonaventura Clotet, Oriol Mitjà, Gèlia Costes, Mar Capdevila-Jáuregui, Pamela Torrano-Soler, Alba San José, Zahida Jiménez, Ferran Ramírez-Viaplana, Susana Ferrer, Mireia Gallardo, Maria Ubals, Camila González-Beiras, Martí Vall-Mayans, Miquel Angel Rodriguez-Arias, Clara Suñer, Jordi Puig, Aroa Nieto, Ivan Galvan-Femenia, Xavier Comas-Leon, Pere Millat-Martínez, Quique Bassat, Bàrbara Baro, Ignacio Blanco, Jordi Ara, Glòria Bonet Papell, Maria Delgado Capel, Beatriz Díez Sánchez, Maria Pons Barber, Cristian Gonzalez Ruiz, Laura Navarrete Gonzalez, David González García, Ainhoa Vivero Larraza, Victor Carceles Peiró, Clàudia Roquer López, Magí Ferrer, Pierre Malchair, Sebastian Videla, Vanesa García García, Carlota Gudiol, Aurema Otero, Jose Carlos Ruibal Suarez, Alvaro Zarauza Pellejero, Ferran Llopis Roca, Orlando Rodriguez Cortez, Pablo Casares Gonzalez, Gemma Arcos Vila, Begoña Flores Aguilera, Graciela Rodríguez-Sevilla, Macarena Dastis Arias, Anna Ruiz-Comellas, Anna Ramírez-Morros, Judit Roca Font, Katherine M. Carrasco Matos, Glòria Saüch Valmaña, Carla Vidal Obradors, Joana Rodríguez Codina, Rosa Amado Simon, Silvia Tarres García, Margarida Curriu Sabatès, Raquel Nieto Rodríguez, Joan-Ramon Grífols, Anna Millan, Enric Contreras, Àgueda Ancochea, Rosa Línio, Miriam Fornos, Natàlia Casamitjana, Eva Alonso, Núria Martinez, Laura Analía Maglio, Laura Comellas Fernandez, Nadia Garcia, Luis Hernández, María Isabel González, Anna Bravo, Yolanda García, Núria Prat, Joaquim Verdaguer, Thatiana Vértiz Guidotti, Sergio Benavent, Andrea Sofia Bianco, Ney Nicanor Briones Zambrano, Maria Viozquez Meya, Anna Forcada, Josep Vidal-Alaball, Montserrat Giménez, Alexa París, Gema Fernández Rivas, Cristina Casañ Lopez, Águeda Hernández, Antoni E. Bordoy, Victoria González Soler, Julian Blanco, Edwars Pradenas, Silvia Marfil, Benjamin Trinité, Francini Piccolo Ferreira, Mireia Bonet, Jordi Cantoni, Michael Marks
[Category] COVID19(2023년), MERS, SARS, 임상, 치료법,
[Article Type] Meta-Analysis
[Source] PMC
Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when <20% of recruitment target was achieved. A Bayesian-adaptive individual patient data meta-analysis was implemented. Outpatients aged ≥50 years and symptomatic for ≤7days were included. The intervention consisted of 200–300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667–1.311); OR for hospitalization or death was 0.919 (CI 0.592–1.416). CP effect on hospital admission or death was largest in patients with ≤5 days of symptoms (OR 0.658, 95%CI 0.394–1.085). CP did not decrease the time to full symptom resolution. Trial registration: Clinicaltrials.gov NCT04621123 and NCT04589949. Registration: NCT04621123 and NCT04589949 on https://www.clinicaltrials.gov Clinical studies have suggested that the therapeutic potential of polyclonal convalescent plasma is highest in the first days of symptoms. Here, the authors present results from a pooled analysis of two clinical trials in COVID-19 outpatients that did not provide conclusive evidence in favor of convalescent plasma.
All Keywords
【저자키워드】 SARS-CoV-2, viral infection, Randomized controlled trials, 【초록키워드】 Treatment, convalescent plasma, Meta-analysis, antibodies, IgG, clinical trial, Hospitalized, mechanical ventilation, Hospitalization, disease severity, randomized trial, Comorbidity, risk, Intervention, Symptom, progression, Symptoms, symptomatic, clinical, Patient, death, Hospital admission, outpatients, multicenter, recruitment, Evidence, Outpatient, Analysis, Odds ratio, double-blind, patient data, Endpoint, 95%CI, median age, therapeutic potential, favor, symptom resolution, Administered, decrease, polyclonal, highest, died, the disease, required, reduced, suggested, COVID-19 outpatient, 【제목키워드】 convalescent plasma, Meta-analysis, randomized trial, Prospective, patient data, COVID-19 outpatient,