[저자] Elodie Meppiel, Nathan Peiffer-Smadja, Alexandra Maury, Imen Bekri, Cécile Delorme, Virginie Desestret, Lucas Gorza, Geoffroy Hautecloque-Raysz, Sophie Landre, Annie Lannuzel, Solène Moulin, Peggy Perrin, Paul Petitgas, François SellaI, Adrien Wang, Pierre Tattevin, Thomas de Broucker, the contributors to the NeuroCOVID registry∗AbgrallSophie14Alby-LaurentFanny15AllouThibault16AmevigbeJoséphine17AmarguellayHanifa18AlloussiNabil19BailleGuillaume20BarbazMathilde21BekriImen22BencherifLamia23BensaadiSamia24BeraudGuillaume25BizotAlexandra26BottinLaure27BruneelFabrice28CamdessancheJean-Philippe29ChauffierJeanne30CsajaghyJean-Philippe31De BrouckerChloé32De BrouckerThomas20DefebvreLuc33DelormeCécile34DembloqueElodie35DeracheNathalie36DereeperOlivier37DerollezCéline33Descotes-GenonCécile38DesestretVirginie39DevauxMathilde40DubucLydie41EdanGilles42FicklAndréa43FraisseThibault44GugenheimMichel45HankiewiczKarolina20HansmannYves46Hautecloque-RayszGeoffroy47HenryCarole20JobardStéphanie48JouanFanny49KwiatkowskiArnaud50LaluThibault51LandreSophie52LannuzelAnnie53LeguillouxJohan54LejeuneCamille55LiegeoisClémence56MahySophie57MareyJonathan58MauryAlexandra20MeppielElodie20MichelLaure59MitriRita60MoulinChloé38MoulinSolène56Peiffer-SmadjaNathan30OmarjeeAsma22OzsancakCanan61PerrinPeggy62PetitgasPaul63PicoFernando22PoupardMarie60RabierValérie64RizzatoCamille65RoosCaroline66SaisonJulien67SayreNaomi60SedillotNicolas68SellalFrançois47ServanJérôme22StoreyCaroline69SuchetLaurent70TarteretPaul71TattevinPierre63ThiebautMathilde72VaduvaClaudia73VarlanDavid20WangAdrien74ZarroukVirginie75Department of Internal Medicine, Hôpital Antoine Béclère, Assistance-Publique Hôpitaux de Paris, 92140, Clamart, FranceDepartment of Infectious Diseases, Hôpital Necker-Enfants Malades Assistance-Publique Hôpitaux de Paris, 75015, Paris, FranceDepartment of Neurology, Hôpital Saint-Jean, 66046, Perpignan, FranceDepartment of Neurology, Hôpital Simone Veil, 60000, Beauvais, FranceDepartment of Oncology and Radiotherapy, Hôpital Simone Veil, 60000, Beauvais, FranceEmergency Department, Hôpital privé Wallerstein, 33740, Arès, FranceDepartment of Neurology, Centre Hospitalier de Saint-Denis, Hôpital Delafontaine, F-93200, Saint-Denis, FranceDepartment of Surgical Critical Care, Centre Hospitalier Universitaire Bretonneau, 37000, Tours, FranceDepartment of Neurology and Stroke Center, Centre Hospitalier de Versailles, 78150, Le Chesnay, FranceDepartment of Neurology, Hôpital de Gonesse, 95500, Gonesse, FranceDepartment of Psychiatry, Hôpital Ville-Evrard, 93332, Neuilly-sur-Marne, FranceDepartment of Infectious Diseases, Centre Hospitalier Universitaire de Poitiers, 86021, Poitiers, FranceDepartment of Oncology, Institut Gustave Roussy, 94800, Villejuif, FranceDepartment of Neurology, Hôpital Saint-Antoine, Assistance-Publique Hôpitaux de Paris, 75012, Paris, FranceDepartment of Intensive Care Medicine, Centre Hospitalier de Versailles, 78150, Le Chesnay, FranceDepartment of Neurology, Hôpital Nord, Centre Hospitalier Universitaire de Saint-Étienne, 42055, Saint-Étienne, FranceDepartment of Infectious Diseases, Bichat-Claude Bernard Hospital, Assistance-Publique Hôpitaux de Paris, Université de Paris, IAME, INSERM, 75018, Paris, FranceEmergency Department, Centre Hospitalier du Haut-Anjou, 53200, Château-Gontier, FranceDepartment of Infectious Diseases, Bichat-Claude Bernard University Hospital, Assistance-Publique Hôpitaux de Paris, 75018, Paris, FranceDepartment of Neurology, Centre Hospitalier Universitaire de Lille, INSERM 1172, 59000, Lille, FranceDepartment of Neurology, Pitié-Salpêtrière Hospital, Assistance-Publique Hôpitaux de Paris, 75013, Paris, FranceDepartement of Obstetrics and Gynecology, Hôpital Simone Veil, 60000, Beauvais, FranceDepartement of Neurology, Secretary of the French Society of Multiple Sclerosis (SF-SEP), Centre Hospitalier Universitaire de Caen, 14000, Caen, FranceDepartment of Neurology, Centre Hospitalier de Calais, 62100, Calais, FranceDepartment of Infectious Diseases, Centre Hospitalier de Chambéry, 73000, Chambéry, FranceDepartment of Neuro-cognition and Neuro-ophthalmology, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, FranceDepartment of Internal Medicine, Centre Hospitalier de Poissy Saint Germain en Laye, 78300, Poissy, FranceDepartment of Neurology, Centre Hospitalier Mémorial, 50000, Saint-Lô, FranceDepartment of Neurology, Centre Hospitalier Universitaire de Rennes, Hôpital Pontchaillou, 35000, Rennes, FranceDepartment of Neurology, Centre Hospitalier Mulhouse, 68100, Mulhouse, FranceDepartment of Geriatric Medicine, Hôpital Alès-Cévennes, 30103, Alès, FrancePresident of the Association of French-Speaking Liberal Neurologists (ANLLF), 78120, Rambouillet, FranceDepartment of Infectious Diseases, Hôpitaux Universitaires de Strasbourg, 67091, Strasbourg, FranceDepartment of Neurology, Hôpitaux civils de Colmar, 68024, Colmar, FranceDepartment of Internal Medicine and Clinical Immunology, Centre Hospitalier Universitaire Bretonneau, 37000, Tours, FranceDepartment of Internal Medicine, Centre Hospitalier de Saint-Denis, Hôpital Delafontaine, F-93200, Saint-Denis, FranceDepartment of Neurology, Hôpital St Vincent de Paul, 59000, Lille, FranceDepartment of Neurology, Centre Hospitalier de Béziers, F-34500, Béziers FranceDepartment of Infectious Diseases, Hospices Civils de Lyon, the University of Lyon, Claude Bernard Lyon 1 University, F-69000, Lyon, FranceDepartment of Neurology, Centre Hospitalier Universitaire de la Guadeloupe, Faculté de médecine de l’université des Antilles, Centre d’investigation clinique Antilles Guyane, Inserm CIC 1424, F-97100, Pointe-à-Pitre, FranceDepartment of Neurology, Hôpital Privé Nord Parisien, 95000, Sarcelles, FranceDepartment of Geriatric Medicine, Centre Hospitalier de Rouffach, 68250, Rouffach, FranceDepartment of Neurology, Centre Hospitalier Universitaire, Hôpital Maison Blanche, F-51092, Reims, FranceDepartment of Internal Medicine, Centre Hospitalier Universitaire Dijon Bourgogne, 21079, Dijon, FranceDepartment of Pneumology, Hôpital Cochin, Assistance-Publique Hôpitaux de Paris, 75014, Paris, FranceDepartment of Neurology, Centre Hospitalier Universitaire de Rennes, Centre d'Investigation Clinique de Rennes (CIC Inserm 1414), 35033, Rennes, FranceDepartment of Infectious Diseases, Centre Hospitalier de Saint-Denis, Hôpital Delafontaine, F-93200, Saint-Denis, FranceDepartment of Neurology, Centre Hospitalier Régional d’Orléans, 45000, Orléans, FranceDepartment of Nephrology, Hôpitaux Universitaires de Strasbourg, 67091, Strasbourg, FranceDepartment of Infectious Diseases and Intensive Care Medicine, Centre Hospitalier Universitaire de Rennes, 35000, Rennes, FranceDepartment of Infectious Diseases, Centre Hospitalier Universitaire d’Angers, 49000, Angers, FranceDepartment of Neurology, Centre Hospitalier Chubert, 56000, Vannes FranceEmergency Headache Center, Hôpital Lariboisière, Assistance-Publique Hôpitaux de Paris, 75010, Paris, FranceDepartment of Infectious Diseases, Centre Hospitalier de Valence, F-26000, Valence, FranceDepartment of Intensive Care Medicine, Centre Hospitalier Fleyriat, 01012, Bourg-en-Bresse, FranceDepartment of Pediatric Endocrinology and Diabetology, Hôpital Robert-Debré, Assistance-Publique Hôpitaux de Paris, 75019, Paris, FranceDepartment of Neurology, Hôpital Européen, 13003, Marseille, FranceDepartment of Infectious Diseases, Centre Hospitalier de Melun, 77000, Melun, FranceDepartment of Internal Medicine, Centre Hospitalier André Grégoire, 93100, Montreuil, FranceDepartment of Neurology, Hôpital Yves le Foll, 22027, Saint-Brieuc, FranceDepartment of Neurology, Hôpital Foch, 92151, Suresnes, FranceDepartment of Internal Medicine, Hôpital Beaujon, Assistance-Publique Hôpitaux de Paris, 92110, Clichy, France
, Sophie Abgrall, Fanny Alby-Laurent, Thibault Allou, Joséphine Amevigbe, Hanifa Amarguellay, Nabil Alloussi, Guillaume Baille, Mathilde Barbaz, Imen Bekri, Lamia Bencherif, Samia Bensaadi, Guillaume Beraud, Alexandra Bizot, Laure Bottin, Fabrice Bruneel, Jean-Philippe Camdessanche, Jeanne Chauffier, Jean-Philippe Csajaghy, Chloé De Broucker, Thomas De Broucker, Luc Defebvre, Cécile Delorme, Elodie Dembloque, Nathalie Derache, Olivier Dereeper, Céline Derollez, Cécile Descotes-Genon, Virginie Desestret, Mathilde Devaux, Lydie Dubuc, Gilles Edan, Andréa Fickl, Thibault Fraisse, Michel Gugenheim, Karolina Hankiewicz, Yves Hansmann, Geoffroy Hautecloque-Raysz, Carole Henry, Stéphanie Jobard, Fanny Jouan, Arnaud Kwiatkowski, Thibault Lalu, Sophie Landre, Annie Lannuzel, Johan Leguilloux, Camille Lejeune, Clémence Liegeois, Sophie Mahy, Jonathan Marey, Alexandra Maury, Elodie Meppiel, Laure Michel, Rita Mitri, Chloé Moulin, Solène Moulin, Nathan Peiffer-Smadja, Asma Omarjee, Canan Ozsancak, Peggy Perrin, Paul Petitgas, Fernando Pico, Marie Poupard, Valérie Rabier, Camille Rizzato, Caroline Roos, Julien Saison, Naomi Sayre, Nicolas Sedillot, François Sellal, Jérôme Servan, Caroline Storey, Laurent Suchet, Paul Tarteret, Pierre Tattevin, Mathilde Thiebaut, Claudia Vaduva, David Varlan, Adrien Wang, Virginie Zarrouk
Objectives To provide an overview of the spectrum, characteristics and outcomes of neurologic manifestations associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods We conducted a single-centre retrospective study during the French coronavirus disease 2019 (COVID-19) epidemic in March–April 2020. All COVID-19 patients with de novo neurologic manifestations were eligible. Results We included 222 COVID-19 patients with neurologic manifestations from 46 centres in France. Median (interquartile range, IQR) age was 65 (53–72) years and 136 patients (61.3%) were male. COVID-19 was severe or critical in 102 patients (45.2%). The most common neurologic diseases were COVID-19–associated encephalopathy (67/222, 30.2%), acute ischaemic cerebrovascular syndrome (57/222, 25.7%), encephalitis (21/222, 9.5%) and Guillain-Barré syndrome (15/222, 6.8%). Neurologic manifestations appeared after the first COVID-19 symptoms with a median (IQR) delay of 6 (3–8) days in COVID-19–associated encephalopathy, 7 (5–10) days in encephalitis, 12 (7–18) days in acute ischaemic cerebrovascular syndrome and 18 (15–28) days in Guillain-Barré syndrome. Brain imaging was performed in 192 patients (86.5%), including 157 magnetic resonance imaging (70.7%). Among patients with acute ischaemic cerebrovascular syndrome, 13 (22.8%) of 57 had multiterritory ischaemic strokes, with large vessel thrombosis in 16 (28.1%) of 57. Brain magnetic resonance imaging of encephalitis patients showed heterogeneous acute nonvascular lesions in 14 (66.7%) of 21. Cerebrospinal fluid of 97 patients (43.7%) was analysed, with pleocytosis found in 18 patients (18.6%) and a positive SARS-CoV-2 PCR result in two patients with encephalitis. The median (IQR) follow-up was 24 (17–34) days with a high short-term mortality rate (28/222, 12.6%). Conclusions Clinical spectrum and outcomes of neurologic manifestations associated with SARS-CoV-2 infection were broad and heterogeneous, suggesting different underlying pathogenic processes.