Abstract
It is critical to identify potential causal targets for SARS-CoV-2, which may guide drug repurposing options. We assessed the associations between genetically predicted protein levels and COVID-19 severity. Leveraging data from the COVID-19 Host Genetics Initiative comparing 6492 hospitalized COVID-19 patients and 1 012 809 controls, we identified 18 proteins with genetically predicted levels to be associated with COVID-19 severity at a false discovery rate of <0.05, including 12 that showed an association even after Bonferroni correction. Of the 18 proteins, 6 showed positive associations and 12 showed inverse associations. In conclusion, we identified 18 candidate proteins for COVID-19 severity.
Keywords: COVID-19 severity; genetic instruments; proteins.
【저자키워드】 COVID-19 severity, Proteins, genetic instruments, 【초록키워드】 COVID-19, SARS-CoV-2, severity, Genetic, Proteins, Protein, target, Critical, association, hospitalized COVID-19 patient, false discovery rate, protein level, positive, Bonferroni correction, initiative, controls, predicted, identify, associations, with COVID-19, 【제목키워드】 COVID-19, Level,