Background The importance of clinicolaboratory characteristics of COVID-19 made us report our findings in the Alborz province according to the latest National Guideline for the diagnosis and treatment of COVID-19 in outpatients and inpatients (trial five versions, 25 March 2020) of Iran by emphasizing rRT-PCR results, clinical features, comorbidities, and other laboratory findings in patients according to the severity of the disease. Methods In this study, 202 patients were included, primarily of whom 164 had fulfilled the inclusion criteria. This cross-sectional, two-center study that involved 164 symptomatic adults hospitalized with the diagnosis of COVID-19 between March 5 and April 5, 2020, was performed to analyze the frequency of rRT-PCR results, distribution of comorbidities, and initial clinicolaboratory data in severe and non-severe cases, comparing the compatibility of two methods for categorizing the severity of the disease. Results According to our findings, 111 patients were rRT-PCR positive (67.6%), and 53 were rRT-PCR negative (32.4%), indicating no significant difference between severity groups that were not related to the date of symptoms’ onset before admission. Based on the National Guideline, among vital signs and symptoms, mean oxygen saturation and frequency of nausea showed a significant difference between the two groups ( P < 0.05); however, no significant difference was observed in comorbidities. In CURB-65 groups, among vital signs and comorbidities, mean oxygen saturation, diabetes, hypertension (HTN), hyperlipidemia, chronic heart disease (CHD), and asthma showed a significant difference between the two groups ( P < 0.05), but no significant difference was seen in symptoms. Conclusion In this study, rRT-PCR results of hospitalized patients with COVID-19 were not related to severity categories. From initial clinical characteristics, decreased oxygen saturation appears to be a more common abnormality in severe and non-severe categories. National Guideline indices seem to be more comprehensive to categorize patients in severity groups than CURB-65, and there was compatibility just in non-severe groups of National Guideline and CURB-65 categories.
【저자키워드】 COVID-19, severe, rRT-PCR, Clinical and laboratory findings, CURB-65, Non-severe, 【초록키워드】 Treatment, Asthma, Hospitalized, Trial, Clinical characteristics, cross-sectional, severity, Comorbidities, Diagnosis, oxygen, Symptom, diabetes, hospitalized patients, hypertension, guideline, Symptoms, Clinical features, Laboratory, laboratory findings, oxygen saturation, rRT-PCR, Iran, Characteristics, CURB-65, Signs and symptoms, Patient, vital signs, vital sign, outpatients, group, distribution, Admission, Frequency, heart disease, CHD, Inpatients, significant difference, two groups, no significant difference, inclusion criteria, categories, nausea, CURB, non-severe group, positive, abnormality, non-severe cases, chronic heart disease, hyperlipidemia, compatibility, severe and non-severe cases, FIVE, initial, Result, involved, the disease, was performed, appear, hospitalized patient, two group, groups, Alborz, diagnosis of COVID-19, outpatients and inpatient, symptomatic adult, with COVID-19, 【제목키워드】 severity, Laboratory, PCR, clinical, WHO, COVID19 patient,