Chemical examination of a South China Sea soft coral Lobophytum sp. led to the isolation of three new α-methylene-γ-lactone-containing cembranoids, (1 R *,3 R *,4 R *,14 R *,7 E ,11 E )-3,4-epoxycembra-7,11,15(17)-trien-16,14-olide ( 1 ), (1 R *,7 S *,14 S *,3 E ,11 E )-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide ( 2 ), and (1 R *,7 S *,14 S *,3 E ,11 E )-18-acetoxy-7-hydroperoxycembra-3,8(19),11,15(17)-tetraen-16,14-olide ( 3 ), along with eleven known analogues 4 – 14 . The structures of the new compounds were elucidated through extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1 – 3 exhibited moderate cytotoxic activity against the selected tumor cell lines. Moreover, 2 and 3 were found to be moderate inhibitors against the bacteria S. aureus and S. pneumoniae .
【저자키워드】 cytotoxicity, antibacterial activity, soft coral, Lobophytum, cembranoids,