Abstract
Introductions: Results with convalescent plasma therapy in coronavirus disease 2019 (COVID-19) have been contradictory. Timing seems to be an important factor for COVID-19 convalescent plasma(CCP) to be effective. Aim of this study is to compare disease outcomes in hospitalized COVID-19 patients who were treated with CCP within first three or seven days of symptoms to patients with symptoms longer than seven days.
Material and methods: A multicenter retrospective study was conducted to evaluate disease outcomes in hospitalized COVID-19 patients who received CCP in addition to standard of care (SOC) approach. Patients were subgrouped according to time of CCP administration; within three days of symptoms, seven days of symptoms and after seven days of symptoms. A control group was formed from age, gender and comorbidity matched hospitalized patients who received SOC treatments without CCP. Length of hospital stay, rates of anti-inflammatory treatment initiation, intensive care unit (ICU) admission and mortality was set as outcome measures.
Results: A total of 223 patients were enrolled in this study, 113 patients received CCP (38 within three days, 63 within seven days, 50 after seven days of symptom onset). Rate of anti-inflammatory treatment initiation was significantly lower (38.1 % vs 62.7 %, p = 0.002, relative risk, 0.60,73; 95 % confidence interval [CI], 0.42 to 0.85) and length of hospital stay was significantly shorter (median(IQR) 8(4) days vs 9.5(5.25) days, p = 0.0025) in patients who received CCP within seven days of symptom onset when compared to SOC group.
Conclusion: CCP therapy may provide better outcomes when applied within seven days of symptoms.
Keywords: COVID-19; Convalescent plasma; Early; Mortality; Outcome.
【저자키워드】 COVID-19, convalescent plasma, Mortality, outcome, early, 【초록키워드】 Treatment, coronavirus disease, intensive care, Comorbidity, Gender, risk, Symptom, outcome, Symptoms, ICU, Retrospective study, Convalescent plasma therapy, Patient, age, multicenter, convalescent, disease, Admission, outcome measures, hospitalized COVID-19 patient, Hospital stay, CCP, Standard of care, symptom onset, confidence interval, control group, material, CCP therapy, significantly lower, approach, effective, Seven, Result, enrolled, evaluate, addition, Rate, conducted, applied, treated, hospitalized patient, Length, 113 patient, anti-inflammatory treatment initiation, significantly shorter, 【제목키워드】 Result,