Introduction Coronavirus disease 2019 (COVID-19), a novel disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to millions of deaths worldwide. Kidney transplant recipients (KTRs) are a fragile population due to their immunosuppressed status. However, there are limited studies available comparing this population with the general population regarding clinical symptoms, and laboratory and imaging features as well as disease severity and clinical outcomes. Methods A total of 24 KTRs and 40 patients from the general population (control group) were enrolled after applying exclusion criteria. Clinical symptoms, laboratory values, and lung involvement patterns in high-resolution computed tomography (HRCT) were compared between KTRs with COVID-19 and their counterparts from the general population. Moreover, the category of disease severity and adverse outcomes such as intensive care unit (ICU) admission, mechanical ventilation (MV), and mortality rate were also compared between these two groups. Results Hypertension was significantly higher among KTRs. Dyspnea was significantly more among the control group ( P = 0.045). There was no significant difference in the rest of clinical symptoms ( P > 0.05). There was no significant difference in CT features as well, except pleural effusion, which was more prevalent in the control group. A lower absolute lymphocytic count (ALC) and platelet count were observed in KTRs. Renal transplant recipients (RTRs) had a higher elevation in creatinine level than their counterparts. The ICU admission, MV, duration of hospital stay, and mortality as adverse outcomes were not significantly different between the KTR and control groups. Conclusion In conclusion, there was no significant difference in the severity and risk of adverse outcomes, including MV, ICU admission, and mortality between KTRs under chronic immunosuppression and the control group.
【저자키워드】 COVID-19, Immunosuppression, Kidney transplantation, Transplant recipients, 【초록키워드】 coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, coronavirus, Mortality, intensive care, Clinical symptoms, mechanical ventilation, severity, lung involvement, disease severity, intensive care unit, risk, severe acute respiratory syndrome Coronavirus, hypertension, Symptoms, clinical outcomes, adverse outcomes, ICU, Laboratory, adverse outcome, Computed tomography, HRCT, clinical, Dyspnea, Patient, ICU admission, death, Platelet, General population, mortality rate, respiratory, disease, Admission, Platelet count, kidney transplant recipients, creatinine, Immunosuppressed, High-resolution, Hospital stay, exclusion criteria, pleural effusion, acute respiratory syndrome, significant difference, control group, two groups, acute respiratory syndrome coronavirus, no significant difference, acute respiratory syndrome coronavirus 2, clinical symptom, control groups, recipient, feature, prevalent, Result, enrolled, caused, significantly more, significantly higher, ALC, not significantly different, with COVID-19, 【제목키워드】 severity, outcome, Laboratory, renal, recipient, radiological features,