Bacterial engagement of specific host tissue structures can be a means of targeting a pathogen to a particular niche, establishing persistent infections and inducing invasion. In this context, primary adhesion is often the first crucial colonization step allowing pathogens to withstand the mechanical clearing mechanisms of the host. As a consequence, bacteria have evolved adhesins with the capacity to mediate interaction between microorganism and host. Here we describe collagen VI as a novel target for adherence of Streptococcus pyogenes and Streptococcus pneumoniae. In upper and lower airways this collagen was distributed in the lamina propria underneath the epithelial basement membrane. Both pathogens exhibited strong affinity to collagen VI as shown by light and electron microscopy in combination with immunodetection and in vitro binding assays. For S. pyogenes this interaction was mediated by M1 protein. The presented data provide evidence for a previously unrecognized role for collagen VI in host-pathogen interplay during respiratory tract infection.
Collagen VI Is a Subepithelial Adhesive Target for Human Respiratory Tract Pathogens
콜라겐 VI는 인간 호흡기 병원체의 상피하 접착 표적이다
[Category] 폐렴구균 감염증,
[Article Type] journal-article
[Source] pubmed
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