Abstract
Feasibility of home blood sample collection methods for the presence of SARS-CoV-2 antibodies from VA Million Veteran Program (MVP) participants was tested to determine COVID-19 infection or vaccination status. Participants (n = 312) were randomly assigned to self-collect blood specimens using the Neoteryx Mitra Clamshell (n = 136) or Tasso-SST (n = 176) and asked to rate their experience. Mitra tip blood was eluted and Tasso tubes were centrifuged. All samples were stored at -80 °C until tested with InBios SCoV-2 Detect™ IgG ELISA, BioRad Platelia SARS-CoV-2 Total Ab Assay, Abbott SARS-CoV-2 IgG and AdviseDx SARS-CoV-2 IgG II assays. Participants rated both devices equally. The Abbott assay had the highest sensitivity (87% Mitra, 98% Tasso-SST) for detecting known COVID infection and/or vaccination. The InBios assay with Tasso-SST had the best sensitivity (97%) and specificity (80%) for detecting known COVID-19 infection and/or vaccination. Veterans successfully collected their own specimens with no strong preference for either device.
Keywords: Antibody; COVID-19; Capillary blood collection; Million Veteran Program; Veterans.
【저자키워드】 COVID-19, antibody, veterans, Veterans., Capillary blood collection, Million Veteran Program, 【초록키워드】 SARS-CoV-2, vaccination, Infection, COVID, sensitivity, specificity, SARS-CoV-2 antibody, COVID-19 infection, capillary, IgG ELISA, SARS-CoV-2 IgG, Blood, Abbott, blood sample, specimen, participant, Abbott SARS-CoV-2 IgG, veteran, Randomly, highest, tested, collected, assays, determine, assigned, Total, asked, centrifuged, Mitra, MVP, was tested, 【제목키워드】 COVID-19 antibody, Blood, specimen, independent,