SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
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【저자키워드】 COVID-19, SARS-CoV-2, spike, variant of concern, L452R, R346K, 【초록키워드】 Vaccine, neutralization, susceptibility, Humoral response, Transmissibility, sera, Lineage, Isolation, molecular, recurrence, SARS-CoV-2 spike, genomic sequencing, humoral, Phenotypes, traits, SARS-CoV-2 isolates, deletions, SARS-CoV-2 strain, single-point mutations, evade, concerning, SARS-CoV-2 isolate, single-point mutation, 【제목키워드】 Italy, lombardy, characterization, isolate,
【저자키워드】 COVID-19, SARS-CoV-2, spike, variant of concern, L452R, R346K, 【초록키워드】 Vaccine, neutralization, susceptibility, Humoral response, Transmissibility, sera, Lineage, Isolation, molecular, recurrence, SARS-CoV-2 spike, genomic sequencing, humoral, Phenotypes, traits, SARS-CoV-2 isolates, deletions, SARS-CoV-2 strain, single-point mutations, evade, concerning, SARS-CoV-2 isolate, single-point mutation, 【제목키워드】 Italy, lombardy, characterization, isolate,
SARS-CoV-2 스파이크는 전염성을 극대화하고 체액 반응을 피하기 위해 진화하고 있습니다. SARS-CoV-2 분리주의 대규모 게놈 시퀀싱은 유리한 표현형과 관련된 핫스팟의 재발을 종종 갖는 단일점 돌연변이 및 결실의 확인으로 이어졌습니다. 우리는 백신 혈청 중화에 대한 감소된 감수성을 보여주는 관련 형질과 이전에 연관되지 않은 계통(C.36)에 속하는 SARS-CoV-2 균주의 분리 및 분자 특성을 보고합니다.