Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives

3-케토-6-O-카바모일-11,12-사이클릭 티오카바메이트 에리트로마이신 A 유도체의 합성과 항균 활성

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Journal: Bioorganic & Medicinal Chemistry Letters
[저자] Bin Zhu, Brett A. Marinelli, Darren Abbanat, Barbara D. Foleno, Karen Bush, Mark J. Macielag
[Category] 폐렴구균 감염증,
Pubmed URL    DOI URL    [DOI] 10.1016/j.bmcl.2007.04.104    
[Article Type] journal-article
[Source] pubmed

A series of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives has been synthesized. The best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria.

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