A diplotype in the lymphotoxin alpha gene is associated with differential expression of LTA mRNA induced by Gram‐positive and Gram‐negative bacteria

림포톡신 알파 유전자에서의 이형접합체는 그람 양성 및 그람 음성 박테리아에 의해 유도된 LTA mRNA의 차별적 발현과 관련이 있다.

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Journal: International Journal of Immunogenetics
[저자] S. E. L. Temple, C. M. Almeida, K. Y. Cheong, R. G. Wunderink, G. W. Waterer
[Category] 폐렴구균 감염증,
Pubmed URL    DOI URL    [DOI] 10.1111/j.1744-313X.2007.00674.x    
[Article Type] journal-article
[Source] pubmed

We sequenced the lymphotoxin alpha (LTA) promoter and identified LTA10G>A in strong linkage with LTA252G>A and LTA723C>A. Stimulated cells from LTA723AA: LTA252GG:LTA10AA individuals had significantly higher LTA mRNA levels than LTA723CC:LTA252AA:LTA10GG and LTA723AA:LTA252AG:LTA10GA individuals, suggesting that this diplotype may contain a functional polymorphism explaining the observed disease associations with LTA252G>A.

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