Abstract
Objective: Large body of studies described individuals with obesity experiencing a worse prognosis in COVID-19. However, the effects of obesity on the prognosis of COVID-19 in patients without comorbidities have not been studied. Therefore, the current study aimed to provide evidence of the relationship between obesity and clinical outcomes in COVID-19 patients without comorbidities.
Methods: A total of 116 hospitalized COVID-19 patients without comorbidities from the ORCHID study (Patients with COVID-19 from the Outcomes Related to COVID-19 Treated with Hydroxychloroquine among Inpatients with Symptomatic Disease) were included. Obesity is defined as a BMI of ≥30 kg/m 2 . A Cox regression analysis was used to estimate the hazard ratio ( HR ) for discharge and death after 28 days.
Results: The percentage of obesity in COVID-19 patients without comorbidities was 54.3% (63/116). Discharge at 28 days occurred in 56/63 (84.2%) obese and 51/53 (92.2%) non-obese COVID-19 patients without comorbidities. Four (3.4%) COVID-19 patients without any comorbidities died within 28 days, among whom 2/63 (3.2%) were obese and 2/53 (3.8%) were non-obese. Multivariate Cox regression analyses showed that obesity was independently associated with a decreased rate of 28-day discharge (adjusted HR : 0.55, 95% CI : 0.35-0.83) but was not significantly associated with 28-day death (adjusted HR : 0.94, 95% CI : 0.18-7.06) in COVID-19 patients without any comorbidities.
Conclusions: Obesity was independently linked to prolonged hospital length of stay in COVID-19 without any comorbidity. Larger prospective trials are required to assess the role of obesity in COVID-19 related deaths.
Keywords: COVID-19; comorbidities; death; discharge; obesity.
【저자키워드】 COVID-19, Comorbidities, discharge, obesity., death, 【초록키워드】 Prognosis, obesity, hospital, Comorbidity, Clinical outcome, BMI, hospitalized COVID-19 patient, Evidence, Cox regression, deaths, COVID-19 patient, Inpatient, Prospective trial, 95% CI, hazard ratio, individual, Cox regression analysis, obese, worse prognosis, multivariate, Effect, defined, described, was used, occurred, died, significantly, required, adjusted, analysis, COVID-19 in patient, with COVID-19, 【제목키워드】 Trial, Clinical outcome, COVID-19 patient, post-hoc analysis,