Abstract
Background: Polyphenols are the largest class of bioactive compounds in plants, which are synthesized as secondary metabolites. In the last few years, interesting studies have demonstrated the efficacy of polyphenols against coronavirus infections.
Methods: we conducted a phase II multicentric clinical trial (TAEROVID-19) during the first wave of the COVID-19 pandemic in order to assess the safety and feasibility of Taurisolo ® aerosol formulation in hospitalized patients suffering from SARS-CoV-2 pneumonia.
Results: we observed a rapid decline of symptoms and a low rate of intensive care in patients treated with Taurisolo ® , with a faster decline of symptoms.
Conclusions: This is the first trial assessing the safety and feasibility of Taurisolo ® aerosol formulation. We could argue that this treatment could act as an add-on therapy in the treatment of COVID-19 patients, owing to both its anti-inflammatory and antioxidant effects. Further controlled trials are needed, which may be of interest to evaluate the compound’s efficacy.
Keywords: COVID-19 pneumonia; ICU access; polyphenols.
【저자키워드】 COVID-19 pneumonia, polyphenols, ICU access, 【초록키워드】 COVID-19, Treatment, Efficacy, clinical trial, therapy, Trial, intensive care, Anti-inflammatory, feasibility, COVID-19 pandemic, Symptom, Symptoms, ICU, Coronavirus infections, plants, Controlled trial, SARS-CoV-2 pneumonia, polyphenol, First wave, COVID-19 patients, secondary metabolites, antioxidant effects, Compound, evaluate, conducted, hospitalized patient, faster, demonstrated, patients treated, 【제목키워드】 COVID-19, phase, Effect,