SARS-CoV-2 represents an unprecedented public health challenge. While the majority of SARS-CoV-2-infected individuals with mild-to-moderate COVID-19 resolve their infection with few complications, some individuals experience prolonged symptoms lasting for weeks after initial diagnosis. Persistent viral infections are commonly accompanied by immunologic dysregulation, but it is unclear if persistent COVID-19 impacts the development of virus-specific cellular immunity. To this end, we analyzed SARS-CoV-2-specific cellular immunity in convalescent COVID-19 patients who experienced eight days or fewer of COVID-19 symptoms or symptoms persisting for 18 days or more. We observed that persistent COVID-19 symptoms were not associated with the development of an overtly dysregulated cellular immune response. Furthermore, we observed that reactivity against the N protein from SARS-CoV-2 correlates with the amount of reactivity against the seasonal human coronaviruses 229E and NL63. These results provide insight into the processes that regulate the development of cellular immunity against SARS-CoV-2 and related human coronaviruses.
【저자키워드】 COVID-19, SARS-CoV-2, T cells, cellular immunity, symptom duration, 【초록키워드】 public health, viral infection, Cellular immune response, Infection, Diagnosis, Symptom, viral infections, Viral, cellular immunity, Impact, N protein, complications, NL63, persistent, COVID-19 symptoms, human coronaviruses, convalescent COVID-19 patients, 229E, regulate, Mild-to-moderate, COVID-19 symptom, dysregulation, Persistent COVID-19 symptoms, infected individuals, individual, SARS-CoV-2-infected individuals, virus-specific cellular immunity, while, initial, human coronaviruses 229E, analyzed, eight, majority, reactivity, dysregulated, the N protein, accompanied, convalescent COVID-19 patient, persistent COVID-19 symptom, SARS-CoV-2-infected individual, 【제목키워드】 Impact, persistent, development,