Abstract
Ivermectin has been found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. It is unknown whether this inhibition of SARS-CoV-2 replication correlates with improved clinical outcomes. To assess the effectiveness and safety of ivermectin in hospitalized patients with COVID-19. A total of 286 patients with COVID-19 were included in the study. Univariate analysis of the primary mortality outcome and comparisons between treatment groups were determined. Logistic regression and propensity score matching (PSM) was used to adjust for confounders. Patients in the ivermectin group received 2 doses of Ivermectin at 200 μg/kg in addition to usual clinical care on hospital Days 1 and 3. The ivermectin group had a significantly higher length of hospital stay than the control group; however, this significance did not maintain on multivariable logistic regression analysis. The length of intensive care unit (ICU) stay and duration of mechanical ventilation were longer in the control group. However, a mortality benefit was not seen with ivermectin treatment before and after PSM (p values = 0.07 and 0.11, respectively). ICU admission, and intubation rate were not significantly different between the groups (p = 0.49, and p = 1.0, respectively). No differences were found between groups regarding the length of hospital stay, ICU admission, intubation rate, and in-hospital mortality.
Keywords: COVID-19; Ivermectin; efficacy; prospective study; safety profile.
【저자키워드】 COVID-19, Ivermectin, Efficacy, Prospective Study, safety profile, 【초록키워드】 SARS-CoV-2, coronavirus, Mortality, intensive care, mechanical ventilation, hospital, in vitro, outcome, clinical outcomes, ICU, Replication, comparison, Effectiveness, ICU admission, clinical care, group, PSM, SARS-CoV-2 replication, safety profile, in-hospital mortality, Analysis, dose, propensity score matching, Hospital stay, acute respiratory syndrome, control group, ivermectin treatment, ivermectin group, multivariable logistic regression, confounders, treatment group, intubation rate, benefit, was used, addition, inhibit, Day, hospitalized patient, maintain, significantly higher, adjust, not significantly different, patients with COVID-19, with COVID-19, 【제목키워드】 hospital,