Abstract
Background and purpose: The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2.
Methods: Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group.
Results: In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection.
Conclusions: Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.
Keywords: COVID-19; SARS-CoV-2; muscle; neurological disorders; precision medicine.
【저자키워드】 COVID-19, SARS-CoV-2, precision medicine, Neurological disorders, muscle, 【초록키워드】 coronavirus, Diseases, Hospitalized, hypoxia, SARS-COV-2 infection, hospital, Infection, nasal, Symptom, headache, Symptoms, Fever, Patient, Manifestations, Encephalopathy, Central nervous system, flu, patients, Hyposmia, Frequency, neurological, acute respiratory syndrome, Precision, control group, throat swabs, positive, transcriptase, neurological manifestation, polymerase chain, enrolled, condition, were used, muscular, patients with SARS-CoV-2, SARS-CoV-2-positive patient, with COVID-19, 【제목키워드】 assessment, neurological manifestation, hospitalized patient, with COVID-19,