The present study was carried out to establish the role of IgG subclasses in leprosy. IgG subclasses to Mycobacterium leprae sonicated antigens (MLSA) and phenolic glycolipid-I (PGL-I) were determined in 124 patients with active leprosy across the disease spectrum and in 76 cases with inactive disease after completion of chemotherapy. IgG2 antibodies were found to be the predominant subclass across the disease spectrum. Lepromatous patients showed elevated levels of IgGI. IgG3 antibody levels were higher in lepromatous than that in tuberculoid patients. Patients with erythema nodosum leprosum showed a significant fall in IgG3 antibody to MLSA. While chemotherapy induced a reduction in IgG1, IgG2 and IgG3 to PGL-I in almost all types of leprous patients, for MLSA the reduction was noticed for these subclasses only in lepromatous patients. IgG4 responses to these antigens were low through out the disease spectrum and did not alter with chemotherapy.
Levels of IgG Subclasses in Active and Inactive Cases in the Disease Spectrum of Leprosy
폐렴구균: 멕시코의 농촌 지역에서 어린이의 비인두 분리물에서 페니실린 내성의 낮은 빈도와 트리메토프림-설파메톡사졸에 대한 높은 내성
[Category] 한센병,
[Article Type] journal-article
[Source] pubmed
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