Abstract
Background: The epidemiology, clinical course, and outcomes of patients with coronavirus disease 2019 (COVID-19) in the Russian population are unknown. Information on the differences between laboratory-confirmed and clinically diagnosed COVID-19 in real-life settings is lacking.
Methods: We extracted data from the medical records of adult patients who were consecutively admitted for suspected COVID-19 infection in Moscow between 8 April and 28 May 2020.
Results: Of the 4261 patients hospitalized for suspected COVID-19, outcomes were available for 3480 patients (median age, 56 years; interquartile range, 45-66). The most common comorbidities were hypertension, obesity, chronic cardiovascular disease, and diabetes. Half of the patients (n = 1728) had a positive reverse transcriptase-polymerase chain reaction (RT-PCR), while 1748 had a negative RT-PCR but had clinical symptoms and characteristic computed tomography signs suggestive of COVID-19. No significant differences in frequency of symptoms, laboratory test results, and risk factors for in-hospital mortality were found between those exclusively clinically diagnosed or with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR. In a multivariable logistic regression model the following were associated with in-hospital mortality: older age (per 1-year increase; odds ratio, 1.05; 95% confidence interval, 1.03-1.06), male sex (1.71; 1.24-2.37), chronic kidney disease (2.99; 1.89-4.64), diabetes (2.1; 1.46-2.99), chronic cardiovascular disease (1.78; 1.24-2.57), and dementia (2.73; 1.34-5.47).
Conclusions: Age, male sex, and chronic comorbidities were risk factors for in-hospital mortality. The combination of clinical features was sufficient to diagnose COVID-19 infection, indicating that laboratory testing is not critical in real-life clinical practice.
Keywords: COVID-19; Russia; SARS-CoV-2; cohort; mortality risk factors.
【저자키워드】 COVID-19, SARS-CoV-2, Russia, Cohort, mortality risk factors., 【초록키워드】 coronavirus disease, coronavirus, Epidemiology, obesity, Comorbidity, Chronic kidney disease, diabetes, outcome, risk factor, RT-PCR, hypertension, Symptoms, Laboratory, Laboratory testing, Computed tomography, Dementia, Clinical course, COVID-19 infection, Patient, Older age, characteristic, disease, Critical, clinical feature, in-hospital mortality, diagnose, Clinical practice, Combination, Frequency, Male sex, Odds ratio, medical record, In-hospital, interquartile range, acute respiratory syndrome, significant difference, 95% confidence interval, clinical symptom, median age, multivariable logistic regression, Russian population, mortality risk factors, positive, laboratory-confirmed, negative RT-PCR, the patient, clinically, diagnosed, diabete, chronic cardiovascular, patients hospitalized, 【제목키워드】 COVID, network, university, city, STOP, Suspected,