Abstract
Background: As the COVID-19 pandemic moves into the survivorship phase, questions regarding long-term lung damage remain unanswered. Previous histopathologic studies are limited to autopsy reports. We studied lung specimens from COVID-19 survivors who underwent elective lung resections to determine whether postacute histopathologic changes are present.
Methods: This multicenter observational study included 11 adult COVID-19 survivors who had recovered but subsequently underwent unrelated elective lung resection for indeterminate lung nodules or lung cancer. We compared these against an age- and procedure-matched control group who never contracted COVID-19 (n = 5) and an end-stage COVID-19 group (n = 3). A blinded pulmonary pathologist examined the lung parenchyma focusing on 4 compartments: airways, alveoli, interstitium, and vasculature.
Results: Elective lung resection was performed in 11 COVID-19 survivors with asymptomatic (n = 4), moderate (n = 4), and severe (n = 3) COVID-19 infections at a median 68.5 days (range 24-142 days) after the COVID-19 diagnosis. The most common operation was lobectomy (75%). Histopathologic examination identified no differences between the lung parenchyma of COVID-19 survivors and controls across all compartments examined. Conversely, patients in the end-stage COVID-19 group showed fibrotic diffuse alveolar damage with intra-alveolar macrophages, organizing pneumonia, and focal interstitial emphysema.
Conclusions: In this study to examine the lung parenchyma of COVID-19 survivors, we did not find distinct postacute histopathologic changes to suggest permanent pulmonary damage. These results are reassuring for COVID-19 survivors who recover and become asymptomatic.
【초록키워드】 COVID-19, macrophages, COVID-19 pandemic, lung, lung cancer, Autopsy, Survivors, Asymptomatic, COVID-19 infection, Patient, COVID-19 diagnosis, Control, age, Diffuse alveolar damage, vasculature, survivorship, change, moderate, Organizing pneumonia, lung parenchyma, airways, lung damage, control group, pathologist, no difference, specimen, COVID-19 group, nodule, pulmonary damage, emphysema, survivor, Elective, interstitial, multicenter observational study, examined, blinded, was performed, median, determine, question, intra-alveolar, lung resection, 【제목키워드】 COVID-19, pulmonary, change,