The progression and distribution of the SARS-CoV-2 pandemic are continuously changing over time and can be traced by blood donors’ serological survey. Here, we investigated the seroprevalence of anti-SARS-CoV-2 antibodies in blood donors in Nuevo Leon, Mexico during 2020 as a strategy for the rapid evaluation of the spread of SARS-CoV-2 and asymptomatic case detection. We collected residual plasma samples from blood donors who attended two regional donation centers from January to December of 2020 to identify changes in anti-SARS-CoV-2 IgG prevalence. Plasma samples were analyzed on the Abbott Architect instrument using the commercial Abbott SARS-CoV-2 IgG chemiluminescent assay. We found a total of 99 reactive samples from 2068 analyzed plasma samples, resulting in a raw prevalence of 4.87%. Donors aged 18–49 years were more likely to be seropositive compared to those aged >50 years ( p < 0.001). Weekly seroprevalence increased from 1.8% during the early pandemic stage to 27.59% by the end of the year. Prevalence was 1.46-fold higher in females compared to males. Case geographical mapping showed that Monterrey city recorded the majority of SARS-CoV-2 cases. These results show that there is a growing trend of seroprevalence over time associated with asymptomatic infection that is unnoticed under the current epidemiological surveillance protocols.
【저자키워드】 COVID-19, Seroprevalence, Blood donors, Mexico, anti-SARS-CoV-2 IgG, 【초록키워드】 SARS-CoV-2, pandemic, SARS-CoV-2 pandemic, Seroprevalence, progression, Spread, Prevalence, anti-SARS-CoV-2 antibodies, Blood donors, Surveillance, anti-SARS-CoV-2 antibody, female, asymptomatic infection, Asymptomatic case, epidemiological, donors, epidemiological surveillance, distribution, seropositive, Blood, Chemiluminescent assay, protocols, Abbott, blood donor, plasma samples, Architect, serological survey, Abbott SARS-CoV-2 IgG, males, reactive, plasma sample, resulting, analyzed, identify, collected, investigated, majority, changes in, recorded, Weekly, the SARS-CoV-2, 【제목키워드】 Blood donors, state,