Abstract
Background: Outcome for critically ill patients with COVID-19 treated with continuous renal replacement therapy (CRRT) is largely unknown. We describe mortality and renal outcome in this group.
Methods: This observational study was conducted at a university hospital in Sweden. We studied critically ill adult COVID-19 patients with Acute Kidney injury (AKI) who received CRRT.
Results: In 451 patients, AKI incidence was 43.7%. 18.2% received CRRT. Median age of CRRT patients was 60 years (IQR 54-65), 90% were male, median BMI was 29 (IQR 25-32), 23.2% had Diabetes, 37.8% hypertension and 6.1% chronic kidney disease prior to admission. 100% required mechanical ventilation. 8.5% received Extra Corporeal Membrane Oxygenation. Median length of stay was 23 days (IQR 15-26). ICU mortality was 39% and 90-day mortality was 45.1%. Age, baseline creatinine values and body weight change were associated with 60 days mortality. Of the survivors, no patients required dialysis at hospital discharge, 73.8% recovered renal function and a median 10.5% of body weight was lost during admission.
Conclusions: Critically ill COVID-19 patients with AKI who received CRRT had a 90-day mortality of 45.1%. At follow-up, three quarters of survivors had recovered renal function. This information is important in the clinical management of COVID-19.
Keywords: Acute kidney injury; COVID-19; Death; Dialysis; Outcomes; Renal recovery; Renal replacement therapy.
【저자키워드】 COVID-19, Acute kidney injury, dialysis, outcomes, death, Renal recovery, renal replacement therapy, 【초록키워드】 therapy, Mortality, mechanical ventilation, Chronic kidney disease, outcome, hypertension, renal function, ICU, kidney, AKI, Critically ill, Survivors, male, Patient, Clinical management, age, Follow-up, incidence, information, Admission, patients, renal replacement therapy, creatinine, Injury, COVID-19 patient, Critically ill patient, university hospital, hospital discharge, CRRT, Median BMI, renal, survivor, required, conducted, median, treated, adult COVID-19 patient, baseline, IQR, with COVID-19, 【제목키워드】 survival, renal replacement therapy, renal, intensive care patient, Continuous,