Abstract
Objective: To explore predictors of severe COVID-19 disease in patients with diabetes hospitalized for COVID-19.
Methods: This is a retrospective observational study of adults with diabetes admitted for COVID-19. Bivariate tests and multivariable Cox regression were used to identify risk factors for severe COVID-19, defined as a composite endpoint of intensive care unit admission/intubation or in-hospital death.
Results: In 1134 patients with diabetes admitted for COVID-19, more severe disease was associated with older age (HR 1.02, p<0.001), male sex (HR 1.28, p=0.017), Asian race (HR 1.34, p=0.029 [reference: white]), and greater obesity (moderate obesity HR 1.59, p=0.015; severe obesity HR 2.07, p=0.002 [reference: normal body mass index]). Outpatient diabetes medications were not associated with outcomes.
Conclusions: Age, male sex, Asian race, and obesity were associated with increased risk of severe COVID-19 disease in adults with type 2 diabetes hospitalized for COVID-19.
Summary: In patients with type 2 diabetes hospitalized for COVID-19 disease, we observed that age, male sex, Asian race, and obesity predicted severe COVID-19 outcomes of intensive care unit admission, intubation, or in-hospital death. The risk conferred by obesity increased with worsening obesity. Outpatient diabetes medications were not observed to be significant predictors of study outcomes.
Keywords: Asian; COVID-19; Mortality; Obesity; Race; Type 2 diabetes mellitus.
【저자키워드】 COVID-19, Mortality, obesity, Type 2 diabetes mellitus, race, Asian, 【초록키워드】 Hospitalized, intensive care, severe COVID-19, Diabetes Mellitus, intubation, risk, outcome, risk factor, COVID-19 disease, outcomes, Patient, Older age, age, predictor, Admission, moderate, severe COVID-19 disease, Outpatient, retrospective, Male sex, severe disease, composite endpoint, In-hospital death, increased risk, worsening, multivariable Cox regression, study outcomes, greater, defined, predicted, identify, were used, Type, diabete, diabetes medication, patients with diabete, type 2 diabete, 【제목키워드】 severe COVID-19, predictor, patients with diabete,