Abstract
Introduction: A mass vaccination campaign against SARS-CoV-2 was initiated in European countries on December 27, 2020. This study compared the antibody response in a sample of healthcare workers (HCWs) who, after the first dose of the BNT162b2 mRNA vaccine, were infected with SARS-CoV-2 (infection group) with the response in a control group of HCWs immunized with two doses (vaccine group).
Methods: This two-arm observational cohort study was carried out using routine health surveillance data obtained from HCWs at Bari Policlinico General Hospital (Italy). The antibody response was determined infection group and vaccine group.
Results: Among the 100 HCWs, 25 (25.0%) were in the infection group and 75 (75.0%) in the full-vaccine group. At the serological evaluation, all of the HCWs tested positive, with a geometric mean titer (GMT) of 7106.8 (95 %CI = 5628.5-8973.4) and a statistically significant difference (p < 0.0001) between the infection group (GMT = 2139.7; 95 %CI = 1310.4-3493.6) and the vaccine group (GMT = 10603.6; 95 %CI = 8698.0-12926.8).
Discussion: Our results shed light on the vaccine response of individuals in different risk categories. It also emphasizes the need for the continued use by HCWs of PPE and good practices during the window between the first and second anti-SARS-CoV-2 vaccinations.
Keywords: Biological risk; COVID-19; Healthcare workers; Immunization; Vaccine.
【저자키워드】 COVID-19, Vaccine, Healthcare workers, immunization, biological risk, 【초록키워드】 SARS-CoV-2, vaccination, Antibody Response, Infection, risk, Italy, anti-SARS-CoV-2, healthcare worker, Health, HCWs, PPE, serological, BNT162b2 mRNA vaccine, Vaccinations, dose, Biological, HCW, Observational cohort study, control group, first dose, individual, statistically significant difference, categories, surveillance data, positive, geometric mean titer, Two-arm, vaccine group, immunized, European country, tested, were infected, carried, was determined, initiated, the vaccine, the antibody response, GMT, 【제목키워드】 SARS-CoV-2, Vaccine, prospective observational study, mRNA, dose, Italian, of BNT162b2,