Abstract
Objective: To determine the presence or absence of SARS-CoV-2 in the cerebrospinal fluid of pregnant women at early stages of COVID-19.
Materials and methods: We conducted a prospective observational study with pregnant women undergoing cesarean section and real-time polymerase chain reaction to SARS-CoV-2 was performed in the cerebrospinal fluid in the early stages of COVID-19.
Results: Fourteen pregnant women, whose COVID-19 symptoms started between four to 18 days prior to delivery, were included. Eleven of the women reported anosmia, dysgeusia, and headaches and there were two fatal cases. SARS-Cov-2 was not present in the cerebrospinal fluid of these COVID-19 patients with early neurological symptoms, even in severe cases.
Conclusion: Our study suggests that peripheric cell damage and parainfectious phenomena may predominate over direct central nervous system injury in the pathophysiology of COVID-19 related early neurological symptoms on pregnant women.
Keywords: COVID-19; Inflammation; Neurology; Pregnancy; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, Inflammation, NEUROLOGY, Pregnancy, 【초록키워드】 prospective observational study, headache, Anosmia, pregnant women, pathophysiology, severe cases, Central nervous system, Neurological symptoms, cerebrospinal fluid, women, early stage, Injury, COVID-19 patient, COVID-19 symptom, material, cell damage, Neurological symptom, polymerase chain, reported, conducted, was performed, determine, absence, 【제목키워드】 pregnant women, early stage, Analysis,