Abstract
Introduction: A number of neurological complications of COVID-19 have been identified, including cranial nerve paralyses. We present a series of 10 patients with lower cranial nerve involvement after severe COVID-19 infection requiring hospitalization in an intensive care unit.
Methods: We conducted a retrospective, observational study of patients admitted to the post-intensive care unit (p-ICU) of Besançon University Hospital (France) between March 16 and May 22, 2020. We included patients with confirmed COVID-19 and cranial neuropathy at admission to the p-ICU. All these patients were treated by orotracheal intubation, and all but one underwent prone-position ventilation therapy.
Results: Of the 88 patients admitted to the p-ICU, 10 patients (11%) presented at least 1 cranial nerve palsy. Of these 10 patients, 9 had a hypoglossal nerve palsy and 8 of these also had a deficit in another cranial nerve. The most frequent association was between hypoglossal and vagal palsies (5 patients). None of the patients developed neurological signs related to a global neuropathy. We found no correlation between the intensity of the motor limb weakness and the occurrence of lower cranial nerve palsies. All but 2 of the patients recovered within less than a month.
Conclusion: The mechanical compressive hypothesis, linked to the prone-position ventilation therapy, appears to be the major factor. The direct toxicity of SARS-CoV-2 and the context of immune dysfunction induced by the virus may be involved in a multifactorial etiology.
Keywords: COVID-19; Intensive care unit; Lower cranial nerve palsy.
【저자키워드】 COVID-19, intensive care unit, Lower cranial nerve palsy., 【초록키워드】 SARS-CoV-2, therapy, intensive care, Hospitalization, Ventilation, intubation, Toxicity, virus, Patient, France, etiology, university, Admission, Care, patients, association, retrospective, Hypothesis, immune dysfunction, Neurological complication, intensity, Severe COVID-19 Infection, weakness, no correlation, Lower, multifactorial, limb, Occurrence, involved, the patient, conducted, treated, appear, less, cranial, neurological sign, 【제목키워드】 palsy, Lower, nerve, Sery,