Abstract
Introduction: Since the outbreak of coronavirus disease 2019 (COVID-19) pandemic, healthcare systems have focused their efforts into finding a treatment to avoid the fatal outcomes of severe acute respiratory syndrome due to coronavirus‑2 (SARS-CoV-2). Benefits and risks of systemic treatments remain unclear, with multiple clinical trials still ongoing. Radiotherapy could play a role in reducing the inflammatory response in the lungs and relieve life-threatening symptoms.
Methods: We designed a prospective study of Ultra-Low Doses of Therapy with Radiation Applied to COVID-19 (ULTRA-COVID) for patients who suffer pneumonia, are not candidates for invasive mechanical ventilation and show no improvement with medical therapy.
Results: We present the preliminary results of two patients diagnosed with COVID-19 pneumonia treated with ULTRA-COVID. After one radiotherapy session, significant clinical response and a good radiological response was observed in both cases, resulting in both patients being discharged from hospital in less than 2 weeks after radiation treatment.
Conclusion: Preliminary clinical and radiological results suggest a potential benefit of treating COVID-19 pneumonia with ULTRA-COVID. ClinicalTrials.gov Identifier: NCT04394182 .
Keywords: COVID-19 pneumonitis; Cytokine storm; Inflamatory response; Radiation; SARS-CoV-2.
【저자키워드】 Cytokine storm, SARS-CoV-2., Radiation, COVID-19 pneumonitis, Inflamatory response, 【초록키워드】 COVID-19, Treatment, coronavirus disease, SARS-CoV-2, clinical trial, pandemic, therapy, Pneumonia, hospital, Prospective Study, lung, risk, outcome, Symptoms, Radiotherapy, outbreak, Patient, Invasive mechanical ventilation, Inflammatory response, Healthcare system, acute respiratory syndrome, clinical response, effort, life-threatening, candidate, treating COVID-19, benefit, radiological, resulting, treated, less, reducing, discharged, diagnosed with COVID-19, 【제목키워드】 COVID-19, Pneumonia, Radiotherapy, dose, treated,