Abstract
Background and objective: The COVID-19 coronavirus disease outbreak is evolving around the world. The aim of this study is to evaluate the association between influenza vaccination and the risk of mortality in hospitalized COVID-19 patients, as well as other risk factors.
Materials and methods: Retrospective observational study. This study was conducted among hospitalized patients with COVID-19 at Hospital La Mancha Centro between March 5 and 25, 2020. Information on influenza vaccination was extracted from electronic medical records. We used a multivariate logistic regression to explore the association between influenza vaccination and mortality from COVID and other risk factors.
Results: 410 patients were included. Influenza vaccine had no effect among COVID-19 hospitalized patients [OR: 1.55 (95%CI: 0.96 – 2.48; p=0.071)]. Increasing hospital mortality was associated with older age [OR: 1.05 (95% CI 1.02-1.07), per year increase; p<0.001)], Charlson ≥3 [OR: 1.84 (95%CI: 1.07-3.15, p=0.027)] and heart failure on admission [OR: 6 (IC95%: 1.6 – 21.7; p=0.007)] CONCLUSIONS: Influenza vaccine had no effect among COVID-19 hospitalized patients. The risk factors identified were older age, higher comorbidity and heart failure on admission.
Keywords: Age; COVID-19; Comorbidity; Comorbilidad; Edad; Hospitalized patients; Influenza vaccine; Mortalidad; Mortality; Pacientes hospitalizados; Vacuna antigripal.
【저자키워드】 COVID-19, Mortality, Comorbidity, hospitalized patients, influenza vaccine, age, Mortalidad, Comorbilidad, Edad, Pacientes hospitalizados, Vacuna antigripal., 【초록키워드】 coronavirus disease, vaccination, Risk factors, Influenza, hospital, risk, risk factor, COVID, heart failure, outbreak, Patient, Older age, electronic medical records, Admission, association, hospitalized COVID-19 patients, 95% CI, multivariate logistic regression, material, evaluate, conducted, hospitalized patient, had no, Increasing, with COVID-19, 【제목키워드】 Evolution, Vaccine, Influenza, hospitalized COVID-19 patient, influence,