Abstract
Objective: To find the clinical and biochemical effects of high-intensity aerobic training with a high-protein diet in children with obesity following COVID-19 infection.
Methods: By using the block randomization method, the eligible participants were randomized into two groups. The first group received high-intensity aerobic training with a high-protein diet (Group A; n = 38) and the second group were allowed to do regular physical activities and eat a regular diet (Group B; n = 38) for 8 weeks. Clinical (basal metabolic index (BMI) and muscle-mass-cross-sectional area (CSA)) and biochemical (Adiponectin, leptin, TNF-α, and IL-6) measures were measured at baseline, on the 8th week, and at 6-months follow-up.
Results: Baseline demographic and clinical attributes show homogenous presentation among the study groups ( p > 0.05). After eight weeks of intervention, and at the end of 6-months follow-up, the basal metabolic index (BMI) (6.3) (CI 95% 4.71 to 7.88), mid-arm CSA (17) (CI 95% 14.70 to 19.29), mid-thigh CSA (13.10) (CI 95% 10.60 to 15.59), mid-calf CSA (11.3) (CI 95% 9.30 to 13.29), adiponectin (-1.9) (CI 95% -2.13 to -1.66), leptin (5.64) (CI 95% 5.50 to 5.77), TNF-α (0.5) (CI 95% 0.42 to 0.57), and IL-6 (0.21) (CI 95% 0.18 to 0.23) showed more improvement ( p < 0.001) in Group A than Group B ( p > 0.05).
Conclusion: Overall, this trial found that high-intensity aerobic training with a high-protein diet decreased the BMI percentile and muscle mass (arm, thigh, and calf), and positively altered the biochemical variables in children with obesity.
Keywords: COVID-19; adipocytokines; aerobic training; children with obesity; high protein diet.
【저자키워드】 COVID-19, adipocytokines, aerobic training, children with obesity, high protein diet., 【초록키워드】 Trial, physical activity, IL-6, children, obesity, Intervention, Randomized, COVID-19 infection, clinical, adiponectin, Follow-up, muscle mass, BMI, CsA, group, TNF-α, two groups, biochemical, measure, block randomization, attribute, variable, Effect, aerobic, eight, homogenous, were measured, baseline, eligible participant, high protein diet, the study group, 【제목키워드】 IL-6, diet, MRI, clinical, adiponectin, BMI, TNF-α, Leptin, training, Effect,