Humoral immunity has emerged as a vital immune component against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nevertheless, a subset of recovered Coronavirus Disease-2019 (COVID-19) paucisymptomatic/asymptomatic individuals do not generate an antibody response, constituting a paradox. We assumed that immunodiagnostic assays may operate under a competitive format within the context of antigenemia, potentially explaining this phenomenon. We present a case where persistent antigenemia/viremia was documented for at least 73 days post-symptom onset using ‘in-house’ methodology, and as it progressively declined, seroconversion took place late, around day 55, supporting our hypothesis. Thus, prolonged SARS-CoV-2 antigenemia/viremia could mask humoral responses, rendering, in certain cases, the phenomenon of ‘non-responders’ a misnomer.
【저자키워드】 COVID-19, SARS-CoV-2, antibody, ELISA, Seroconversion, Viremia, antigenemia, immunoprevalence, non-responders, immunodiagnostics, 【초록키워드】 coronavirus disease, coronavirus, Immunity, Antibody Response, severe acute respiratory syndrome Coronavirus, immune, coronavirus disease-2019, Humoral immunity, Seroconversion, Viremia, antigenemia, humoral responses, methodology, respiratory, Hypothesis, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, house, phenomenon, individual, post-symptom onset, responders, misnomer, paradox, generate, subset, declined, assumed, took place, 【제목키워드】 Factor, Confounding,