Abstract
Background: The role of repeated prone positioning in intubated subjects with acute respiratory distress syndrome caused by COVID-19 remains unclear.
Methods: We conducted a retrospective observational cohort study of critically ill intubated patients with COVID-19 who were placed in the prone position between March 18, 2020 and March 31, 2020. Exclusion criteria were pregnancy, reintubation, and previous prone positioning at a referring hospital. Patients were followed up until hospital discharge. The primary outcome was oxygenation assessed by partial pressure of oxygen/fraction of inspired oxygen ratio (Pao 2 /Fio 2 ) ratio. A positive response to proning was defined as an increase in Pao 2 /Fio 2 ratio ≥20%. Treatment failure of prone positioning was defined as death or requirement for extracorporeal membrane oxygenation (ECMO).
Results: Forty-two subjects (29 males; age: 59 [52-69] yr) were eligible for analysis. Nine subjects were placed in the prone position only once, with 25 requiring prone positioning on three or more occasions. A total of 31/42 (74%) subjects survived to discharge, with five requiring ECMO; 11/42 (26%) subjects died. After the first prone positioning session, Pao 2 /Fio 2 (mean (standard deviation)) ratio increased from 17.9 kPa (7.2) to 28.2 kPa (12.2) (P<0.01). After the initial prone positioning session, subjects who were discharged from hospital were more likely to have an improvement in Pao 2 /Fio 2 ratio ≥20%, compared with those requiring ECMO or who died.
Conclusion: Patients with COVID-19 acute respiratory distress syndrome frequently responded to initial prone positioning with improved oxygenation. Subsequent prone positioning in subjects discharged from hospital was associated with greater improvements in oxygenation.
Keywords: COVID-19; acute respiratory distress syndrome (ARDS); mechanical ventilation; oxygenation; prone positioning.
【저자키워드】 COVID-19, mechanical ventilation, acute respiratory distress syndrome (ARDS), Oxygenation, prone positioning, 【초록키워드】 Prone position, hospital, oxygen, discharge, extracorporeal membrane oxygenation, Pregnancy, Critically ill, death, ECMO, acute respiratory distress, retrospective, Analysis, prone positioning, criteria, Observational cohort study, Intubated, Primary outcome, subject, hospital discharge, syndrome, positive response, proning, repeated, FIVE, initial, greater, defined, caused, died, conducted, increase in, discharged, survived, eligible, improvements in oxygenation, intubated patient, kPa, with COVID-19, 【제목키워드】 ARDS, prone, Patient, acute respiratory distress, retrospective, Observational cohort study, Intubated, syndrome,