Abstract
Introduction: There has been limited data on the influence of sex on development of thrombosis in patients with coronavirus disease 2019 (COVID-19).
Materials and methods: The CLOT-COVID Study was a retrospective, multicenter cohort study enrolling 2894 consecutive hospitalized patients with COVID-19 among 16 centers in Japan from April 2021 to September 2021. We divided the entire cohort into the men (N = 1885) and women (N = 1009) groups.
Results: There were no significant differences in D-dimer levels at admission between men and women. Men had more severe status of the COVID-19 at admission compared with women (Mild: 57% versus 66%, Moderate: 34% versus 29%, and Severe: 9.1% versus 5.7%, P < 0.001). Men more often received pharmacological thromboprophylaxis than women (47% versus 35%, P < 0.001). During the hospitalization, men more often developed thrombosis than women (2.5% [95%CI, 1.9-3.3%] versus 0.8% [95%CI, 0.4-1.6%], P = 0.001). Men had numerically higher incidences of thrombosis than women in all subgroups of the worst severity of COVID-19 during the hospitalization (Mild: 0.3% versus 0.0%, Moderate: 1.6% versus 1.0%, and Severe: 11.1% versus 4.3%). Even after adjusting confounders in the multivariable logistic regression model, the excess risk of men relative to women remained significant for thrombosis (adjusted OR, 2.51; 95%CI, 1.16-5.43, P = 0.02).
Conclusions: In the current large observational study of patients with COVID-19, men had more severe status of the COVID-19 than women, and the risk of development of thrombosis was higher in men compared with women, which could be helpful in determining the patient-specific optimal management strategies for COVID-19.
Keywords: COVID-19; Sex; Thrombosis.
【저자키워드】 COVID-19, thrombosis, Sex, 【초록키워드】 coronavirus disease, thrombosis, Hospitalization, risk, severity of COVID-19, management, Patient, Japan, women, incidence, Admission, Thromboprophylaxis, retrospective, D-dimer level, subgroup, 95%CI, no significant difference, multivariable logistic regression, entire cohort, material, pharmacological, men, confounder, multicenter cohort study, remained, adjusted, hospitalized patient, groups, men and women, had more, patients with COVID-19, with COVID-19, 【제목키워드】 thrombosis, Patient, influence,