This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH and 53 HIV-negative individuals aged 18–59 years who had received an inactivated SARS-CoV-2 vaccine in two Chinese cities between April and June 2021. Blood samples were tested for immunogenicity of the inactivated SARS-CoV-2 vaccines. The prevalence and severity of adverse events associated with SARS-CoV-2 vaccines were similar between PLWH and HIV-negative individuals. The seropositivity of neutralizing activity against authentic SARS-CoV-2, of the total amount of antibody (total antibody) and of S-IgG were 71.3%, 81.9%, and 92.6%, respectively, among fully vaccinated PLWH. Among all participants, PLWH had lower neutralizing activity, total antibody, S-IgG, and T-cell-specific immune response levels, compared to HIV-negative individuals, after controlling for types of vaccine, time interval between first and second dose, time after receiving the second dose, and sociodemographic factors. PLWH with a longer interval since HIV diagnosis, who received their second dose 15–28 days prior to study commencement, and who had an interval of ≥21 days between first and second dose had higher neutralizing activity levels. The immunogenicity of the inactivated SARS-CoV-2 vaccines was lower among PLWH as compared to HIV-negative individuals. Vaccination guideline specific for PLWH should be developed.
【저자키워드】 people living with HIV, inactivated SARS-CoV-2 vaccines, self-reported adverse events, neutralizing activity responses against authentic SARS-CoV-2, total antibody specific to SARS-CoV-2, SARS-CoV-2 IgG antibody, antigen-specific T-cell immune response, 【초록키워드】 SARS-CoV-2, HIV, Vaccine, immune response, immunogenicity, antibody, severity, Diagnosis, SARS-CoV-2 vaccines, SARS-CoV-2 vaccine, adverse events, Prevalence, Neutralizing activity, adverse event, Seropositivity, T-cell, PLWH, inactivated, time interval, Participants, Blood samples, HIV-negative, second dose, All participants, individual, blood sample, Chinese, sociodemographic factors, first and second dose, tested, recruited, receiving, individuals, with HIV, 【제목키워드】 SARS-CoV-2, China, response, with HIV,