Abstract
Background: Determining the factors affecting the mortality and clinical conditions of the patients with Covid-19 are indispensable needs in developing patient treatment algorithms. We aimed to determine the parameters that can predict the mortality of moderate to severely ill patients with laboratory confirmed Covid-19.
Methods: Moderate to severely ill, Covid-19 patients older than 18 years were included. Mild Covid-19 patients and the ones with negative polymerase chain reaction test results were excluded from the study. The primary outcome of the study was 30-day mortality rate and we aimed to determine the factors affecting mortality in moderate to severely ill Covid-19 patients.
Results: 168 patient results were analyzed. Median age of the patients was 59.5 (48.3 to 76) and 90 (53.6%) were male. According to multivariate regression analysis results, the presence of any comorbid disease (p = 0.027, HR = 26.11 (95%CI: 1.45 to 471.31)), elevated C-reactive protein levels (CRP) (p < 0.001, HR = 1.24 (95%CI: 1.11 to 1.38)) and presence of dyspnea (p = 0.026, HR = 4.26 ((95%CI: 1.19 to 15.28)) were found to significantly increase the mortality, while high pulse O 2 saturation level (p < 0.001, HR = 0.90 (95%CI: 0.82 to 0.99) was found to decrease. When receiver operating characteristic curve was created for laboratory tests, it was determined that white blood cell counts, neutrophil counts, CRP levels and neutrophil/lymphocyte ratio predicted mortality while Lymphocyte levels did not.
Conclusion: Dyspnea, the presence of any comorbid disease, elevated CRP levels, and low pulse O 2 saturation levels predict mortality in moderate to severely ill Covid-19 patients.
Keywords: 2019 novel coronavirus disease; COVID-19 pandemic; Mortality; SARS-CoV-2 infection.
【저자키워드】 2019 novel coronavirus disease, Mortality, SARS-COV-2 infection, COVID-19 pandemic, 【초록키워드】 COVID-19, SARS-COV-2 infection, C-reactive protein, CRP, Laboratory tests, Novel coronavirus, Laboratory, White blood cell, Dyspnea, male, Patient, age, characteristic, disease, moderate, patients, predict, regression analysis, Factor, Algorithms, Primary outcome, CRP levels, neutrophil counts, clinical condition, CRP level, pulse, parameter, patient treatment, decrease, 30-day mortality rate, polymerase chain, predicted, analyzed, significantly, the patient, elevated, was determined, determine, affecting, Determining, patients older, severely ill patient, were excluded, 【제목키워드】 predictor, moderate, severely ill patient,